GHTM

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Home / Archives for Carrilho E

Morphological characteristics of Schistosoma mansoni PZQ-resistant and -susceptible strains are different in presence of Praziquantel

  • Authors: Afonso A, Allegretti SM, Anibal FF, Belo S, Carrilho E, Corrêa SAP, de Oliveira RN, Mendes T, Pinto-Almeida A, Tomas A
  • Publication Year: 2016
  • Journal: Frontiers in Microbiology
  • Link: https://www.frontiersin.org/articles/10.3389/fmicb.2016.00594/full

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The role of efflux pumps in Schistosoma mansoni Praziquantel resistant phenotype

  • Authors: Afonso A, Armada A, Belo S, Carrilho E, Mendes T, Pinto-Almeida A, Viveiros M
  • Publication Year: 2015
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140147%20

Schistosomiasis is a neglected disease caused by a trematode of the genus Schistosoma that is second only to malaria in public health significance in Africa, South America, and Asia. Praziquantel (PZQ) is the drug of choice to treat this disease due to its high cure rates and no significant side effects. However, in the last […]
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Participation of leukotrienes in the immune modulation of oral tolerance

  • Authors: Afonso A, Carrilho E, de Freitas Anibal F, de Matos AP, de Oliveira SR, Faccioli LH, Frantz FG, Nomizo A
  • Publication Year: 2017
  • Journal: Frontiers in Microbiology
  • Link: https://www.frontiersin.org/articles/10.3389/fmicb.2017.00242/full

Oral tolerance (OT) is characterized as a peripheral immune tolerance form, in which, mature lymphocytes in lymphoid tissues associated with mucosa, become non-functional or hypo responsive due to prior oral administration of antigen. OT is an important immunological phenomenon due to its therapeutic potential in inflammatory processes and others diseases. Here we evaluated leukotriene role […]
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Endothelial Cell Culture Under Perfusion On A Polyester-Toner Microfluidic Device

  • Authors: Afonso A, Cappelini LTD, Carlos IZ, Carrilho E, De Sousa FZR, Leão PAGC, Urbaczek AC, Alberice JV
  • Publication Year: 2017
  • Journal: Scientific Reportsvolume
  • Link: https://www.nature.com/articles/s41598-017-11043-0

This study presents an inexpensive and easy way to produce a microfluidic device that mimics a blood vessel, serving as a start point for cell culture under perfusion, cardiovascular research, and toxicological studies. Endpoint assays (i.e., MTT reduction and NO assays) were used and revealed that the components making up the microchip, which is made […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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