Morphological characteristics of Schistosoma mansoni PZQ-resistant and -susceptible strains are different in presence of Praziquantel

Authors: Afonso A, Allegretti SM, Anibal FF, Belo S, Carrilho E, Corrêa SAP, de Oliveira RN, Mendes T, Pinto-Almeida A, Tomas A
Publication Year: 2016
Journal: Frontiers in Microbiology
Link: https://www.frontiersin.org/articles/10.3389/fmicb.2016.00594/full

Authors: Afonso A, Armada A, Belo S, Carrilho E, Mendes T, Pinto-Almeida A, Viveiros M
Publication Year: 2015
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140147%20

Schistosomiasis is a neglected disease caused by a trematode of the genus Schistosoma that is second only to malaria in public health significance in Africa, South America, and Asia. Praziquantel (PZQ) is the drug of choice to treat this disease due to its high cure rates and no significant side effects. However, in the last […]
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Randomly amplified polymorphic DNA (RAPD) polymerase chain reaction assay for comparison of Schistosoma mansoni strains sensitive and resistant to praziquantel.

Authors: Afonso A, Belo S, Calado M, Clemente I, Ferreira CC, Ferreira PM, Figueira AR, Grácio MA, Maurício I, Mendes T, Santos R
Journal: Tropical Medicine & International Health
Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=2&SID=2CbhBUDoSw8ZkFBEQLW&page=1&doc=1

Authors: Afonso A, Belo S, Calado M, Clemente I, Ferreira CC, Ferreira PM, Figueira AR, Graco MA, Maurício I, Mendes T
Journal: Tropical Medicine & International Health
Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=2CbhBUDoSw8ZkFBEQLW&page=1&doc=1

Authors: Clemente I, Freitas CP, Mendes T, Novo C
Publication Year: 2014
Journal: Journal of Helminthology
Link: http://www.ncbi.nlm.nih.gov/pubmed/25475092

The formation of nurse cells in host muscle cells during Trichinella spiralis infection is a key step in the infective mechanism. Collagen trimerization is set up via disulphide bond formation, catalysed by protein disulphide isomerase (PDI). In T. spiralis, some PDI family members have been identified but no localization is described and no antibodies specific for T. spiralis PDIs are available. In this work, computational approaches were used to search for non-described PDIs in the T. spiralis genome database and to check the cross-reactivity of commercial anti-human antibodies with T. spiralis orthologues.
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Morphological characteristics of Schistosoma mansoni PZQ-resistant and -susceptible strains are different in presence of Praziquantel

The role of efflux pumps in Schistosoma mansoni Praziquantel resistant phenotype

Randomly amplified polymorphic DNA (RAPD) polymerase chain reaction assay for comparison of Schistosoma mansoni strains sensitive and resistant to praziquantel.

Immunological and genetical analysis of combined therapy with artemisinin-praziquantel in Schistosoma mansoni in vivo.

Trichinella spiralis: Genome database searches for the presence and immunolocalization of protein disulphide isomerase family members

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