Trichinella spiralis: Genome database searches for the presence and immunolocalization of protein disulphide isomerase family members

Authors: Clemente I, Freitas CP, Mendes T, Novo C
Publication Year: 2014
Journal: Journal of Helminthology
Link: http://www.ncbi.nlm.nih.gov/pubmed/25475092

The formation of nurse cells in host muscle cells during Trichinella spiralis infection is a key step in the infective mechanism. Collagen trimerization is set up via disulphide bond formation, catalysed by protein disulphide isomerase (PDI). In T. spiralis, some PDI family members have been identified but no localization is described and no antibodies specific for T. spiralis PDIs are available. In this work, computational approaches were used to search for non-described PDIs in the T. spiralis genome database and to check the cross-reactivity of commercial anti-human antibodies with T. spiralis orthologues.
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The role of the immunological background of mice in the genetic variability of Schistosoma mansoni as detected by random amplification of polymorphic DNA

Schistosomiasis is a parasitic disease caused by flatworms of the genus Schistosoma. Among the Schistosomaspecies known to infect humans, S. mansoni is the most frequent cause of intestinal schistosomiasis in sub-Saharan Africa and South America: the World Health Organization estimates that about 200,000 deaths per year result from schistosomiasis in sub-Saharan Africa alone. The Schistosoma life cycle requires two different hosts: a snail as intermediate host and a mammal as definitive host.
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Trichinella spiralis: Genome database searches for the presence and immunolocalization of protein disulphide isomerase family members

The role of the immunological background of mice in the genetic variability of Schistosoma mansoni as detected by random amplification of polymorphic DNA

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