Molecular characterization of Dirofilaria spp. circulating in Portugal

Authors: Afonso A, Alho AM, Belo S, Calado M, Ferreira C, Madeira de Carvalho L, Maurício I, Meireles J
Publication Year: 2017
Journal: Parasites & Vectors
Link: https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-017-2180-y

Dirofilariosis is a potentially zoonotic parasitic disease, mainly transmitted by mosquito vectors in many parts of the world. Data concerning the canine Dirofilaria species currently circulating in Portugal is scarce. Thereby, a large-scale study was conducted to determine the Dirofilaria spp. present in Portugal, based on a molecular approach, and also to optimize a reliable […]
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Endothelial Cell Culture Under Perfusion On A Polyester-Toner Microfluidic Device

Authors: Afonso A, Cappelini LTD, Carlos IZ, Carrilho E, De Sousa FZR, Leão PAGC, Urbaczek AC, Alberice JV
Publication Year: 2017
Journal: Scientific Reportsvolume
Link: https://www.nature.com/articles/s41598-017-11043-0

This study presents an inexpensive and easy way to produce a microfluidic device that mimics a blood vessel, serving as a start point for cell culture under perfusion, cardiovascular research, and toxicological studies. Endpoint assays (i.e., MTT reduction and NO assays) were used and revealed that the components making up the microchip, which is made […]
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Anti-inflammatory properties of menthol and menthone in Schistosoma mansoni infection

Authors: Afonso A, Allegretti SM, Anibal FF, Cagnazzo TDO, Faccioli LH, Feitosa KA, Soares EG, Zaia MG
Publication Year: 2016
Journal: Frontiers in Pharmacology
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911957/

Schistosomiasis is a parasitic disease caused by several species of trematode worms and it is believed that more than 261 million people are affected worldwide. New drug development has become essential because there is a risk of the parasite becoming resistant to Praziquantel, the only drug available for this infection. This study evaluated parasitological, immunological […]
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Curcumin generates oxidative stress and induces apoptosis in adult schistosoma mansoni worms

Authors: Afonso A, Belo S, Cunha WR, Curti C, De Aguiar DP, De Paula RG, Ferreira PM, Magalhães LG, Morais ER, Moscardini MBM, Ouchida AT, Rodrigues V
Publication Year: 2016
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167135

Inducing apoptosis is an interesting therapeutic approach to develop drugs that act against helminthic parasites. Researchers have investigated how curcumin (CUR), a biologically active compound extracted from rhizomes of Curcuma longa, affects Schistosoma mansoni and several cancer cell lines. This study evaluates how CUR influences the induction of apoptosis and oxidative stress in couples of […]
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Molecular characterization of the first record of Lymnaea natalensis Krauss 1848 (Mollusca, Pulmonata, Lymnaeidae) on Madeira Island.

Authors: Afonso A, Belo S, Brehm A, Calado M, Ferreira CC, Ferreira PM, Grácio MA, Maurício I, Parreira R
Journal: Tropical Medicine & International Health
Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=31&SID=Y2ytOr2frNCuRlReLtM&page=1&doc=1

Molecular characterization of Dirofilaria spp. circulating in Portugal

Endothelial Cell Culture Under Perfusion On A Polyester-Toner Microfluidic Device

Anti-inflammatory properties of menthol and menthone in Schistosoma mansoni infection

Curcumin generates oxidative stress and induces apoptosis in adult schistosoma mansoni worms

Molecular characterization of the first record of Lymnaea natalensis Krauss 1848 (Mollusca, Pulmonata, Lymnaeidae) on Madeira Island.

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