GHTM

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Home / Archives for Afonso A

Molecular characterization of Dirofilaria spp. circulating in Portugal

  • Authors: Afonso A, Alho AM, Belo S, Calado M, Ferreira C, Madeira de Carvalho L, Maurício I, Meireles J
  • Publication Year: 2017
  • Journal: Parasites & Vectors
  • Link: https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-017-2180-y

Dirofilariosis is a potentially zoonotic parasitic disease, mainly transmitted by mosquito vectors in many parts of the world. Data concerning the canine Dirofilaria species currently circulating in Portugal is scarce. Thereby, a large-scale study was conducted to determine the Dirofilaria spp. present in Portugal, based on a molecular approach, and also to optimize a reliable […]
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Endothelial Cell Culture Under Perfusion On A Polyester-Toner Microfluidic Device

  • Authors: Afonso A, Cappelini LTD, Carlos IZ, Carrilho E, De Sousa FZR, Leão PAGC, Urbaczek AC, Alberice JV
  • Publication Year: 2017
  • Journal: Scientific Reportsvolume
  • Link: https://www.nature.com/articles/s41598-017-11043-0

This study presents an inexpensive and easy way to produce a microfluidic device that mimics a blood vessel, serving as a start point for cell culture under perfusion, cardiovascular research, and toxicological studies. Endpoint assays (i.e., MTT reduction and NO assays) were used and revealed that the components making up the microchip, which is made […]
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Anti-inflammatory properties of menthol and menthone in Schistosoma mansoni infection

  • Authors: Afonso A, Allegretti SM, Anibal FF, Cagnazzo TDO, Faccioli LH, Feitosa KA, Soares EG, Zaia MG
  • Publication Year: 2016
  • Journal: Frontiers in Pharmacology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911957/

Schistosomiasis is a parasitic disease caused by several species of trematode worms and it is believed that more than 261 million people are affected worldwide. New drug development has become essential because there is a risk of the parasite becoming resistant to Praziquantel, the only drug available for this infection. This study evaluated parasitological, immunological […]
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Curcumin generates oxidative stress and induces apoptosis in adult schistosoma mansoni worms

  • Authors: Afonso A, Belo S, Cunha WR, Curti C, De Aguiar DP, De Paula RG, Ferreira PM, Magalhães LG, Morais ER, Moscardini MBM, Ouchida AT, Rodrigues V
  • Publication Year: 2016
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167135

Inducing apoptosis is an interesting therapeutic approach to develop drugs that act against helminthic parasites. Researchers have investigated how curcumin (CUR), a biologically active compound extracted from rhizomes of Curcuma longa, affects Schistosoma mansoni and several cancer cell lines. This study evaluates how CUR influences the induction of apoptosis and oxidative stress in couples of […]
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Molecular characterization of the first record of Lymnaea natalensis Krauss 1848 (Mollusca, Pulmonata, Lymnaeidae) on Madeira Island.

  • Authors: Afonso A, Belo S, Brehm A, Calado M, Ferreira CC, Ferreira PM, Grácio MA, Maurício I, Parreira R
  • Journal: Tropical Medicine & International Health
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=31&SID=Y2ytOr2frNCuRlReLtM&page=1&doc=1

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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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