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Home / Archives for Frontiers in Pharmacology

CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region

  • Autores: Paula Ferreira Salles, Daiana Souza Perce-da-Silva, Atila Duque Rossi, Luisa Riehl Raposo, Aina Danaisa Ramirez Ramirez, Otílio Machado Pereira Bastos, Lilian Rose Pratt-Riccio, Gustavo Capatti Cassiano, Andrea Regina Souza Baptista, Cynthia Chester Cardoso, Dalma Maria Banic, Ricardo Luiz Dantas Machado
  • Ano de Publicação: 2021
  • Journal: Frontiers in Pharmacology, 12, art 542342
  • Link: https://doi.org/10.3389/fphar.2021.542342

ABSTRACT Genetic variability was linked with individual responses to treatment and susceptibility to malaria by Plasmodium vivax. Polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. The aim of the study was to investigate whether or not CYP2D6 single nucleotide polymorphisms rs1065852, rs38920-97, rs16947 and rs28371725 are unequally distributed […]
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QSAR-driven design and discovery of novel compounds with antiplasmodial and transmission blocking activities

  • Autores: Lima MNN, Melo-Filho CC, Cassiano GC, Neves BJ, Alves VM, Braga RC, Cravo P, Muratov EN, Calit J, Bargieri DY, Costa FT, Andrade CH
  • Ano de Publicação: 2018
  • Journal: Frontiers in Pharmacology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845645/%20

Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved resistance to all current antimalarial drugs, urging for the discovery of new effective compounds. Given that the inhibition of […]
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Menthol and Menthone Associated with Acetylsalicylic Acid and Their Relation to the Hepatic Fibrosis in Schistosoma mansoni Infected Mice

  • Autores: Feitosa KA, Zaia MG, Rodrigues V, Castro CA, Correia RO, Pinto FG, Rossi KNZP, Avó LRS, Afonso A, Anibal FF
  • Ano de Publicação: 2018
  • Journal: Frontiers in Pharmacology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778335/

Schistosomiasis is an important parasitic disease caused by Schistosoma mansoni, an intravascular trematode. Schistosomiasis treatment is limited to just one drug, Praziquantel (PZQ). Thus, studies on new antischistosomal compounds are of fundamental importance to disease control. Here we report on the effects of Mentha piperita L. compounds – menthol and menthone – in association with acetylsalicylic acid (ASA) […]
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Anti-inflammatory properties of menthol and menthone in Schistosoma mansoni infection

  • Autores: Afonso A, Allegretti SM, Anibal FF, Cagnazzo TDO, Faccioli LH, Feitosa KA, Soares EG, Zaia MG
  • Ano de Publicação: 2016
  • Journal: Frontiers in Pharmacology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911957/

Schistosomiasis is a parasitic disease caused by several species of trematode worms and it is believed that more than 261 million people are affected worldwide. New drug development has become essential because there is a risk of the parasite becoming resistant to Praziquantel, the only drug available for this infection. This study evaluated parasitological, immunological […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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