In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases

Only ~1% of all drug candidates against Neglected Tropical Diseases (NTDs) have reached clinical trials in the last decades, underscoring the need for new, safe and effective treatments. In such context, drug repositioning, which allows finding novel indications for approved drugs whose pharmacokinetic and safety profiles are already known, emerging as a promising strategy for […]
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QSAR-driven design and discovery of novel compounds with antiplasmodial and transmission blocking activities

Autores: Lima MNN, Melo-Filho CC, Cassiano GC, Neves BJ, Alves VM, Braga RC, Cravo P, Muratov EN, Calit J, Bargieri DY, Costa FT, Andrade CH
Ano de Publicação: 2018
Journal: Frontiers in Pharmacology
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845645/%20

Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved resistance to all current antimalarial drugs, urging for the discovery of new effective compounds. Given that the inhibition of […]
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In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases

QSAR-driven design and discovery of novel compounds with antiplasmodial and transmission blocking activities

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