QSAR-driven design and discovery of novel compounds with antiplasmodial and transmission blocking activities
- Authors: Lima MNN, Melo-Filho CC, Cassiano GC, Neves BJ, Alves VM, Braga RC, Cravo P, Muratov EN, Calit J, Bargieri DY, Costa FT, Andrade CH
- Publication Year: 2018
- Journal: Frontiers in Pharmacology
- Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845645/%20
Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved resistance to all current antimalarial drugs, urging for the discovery of new effective compounds. Given that the inhibition of […]
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