CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region

• Autores: Paula Ferreira Salles, Daiana Souza Perce-da-Silva, Atila Duque Rossi, Luisa Riehl Raposo, Aina Danaisa Ramirez Ramirez, Otílio Machado Pereira Bastos, Lilian Rose Pratt-Riccio, Gustavo Capatti Cassiano, Andrea Regina Souza Baptista, Cynthia Chester Cardoso, Dalma Maria Banic, Ricardo Luiz Dantas Machado
• Ano de Publicação: 2021
• Journal: Frontiers in Pharmacology, 12, art 542342
• Link: https://doi.org/10.3389/fphar.2021.542342

ABSTRACT Genetic variability was linked with individual responses to treatment and susceptibility to malaria by Plasmodium vivax. Polymorphisms in the CYP2D6 gene may modulate enzyme level and activity, thereby affecting individual responses to pharmacological treatment. The aim of the study was to investigate whether or not CYP2D6 single nucleotide polymorphisms rs1065852, rs38920-97, rs16947 and rs28371725 are unequally distributed […]
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