Zika genomics urgently need standardized and curated reference sequences

Authors: Abecasis AB, Cuypers L, Dallmeier K, Libin P, Pineda-Peña AC, Theys K, Vandamme AM
Publication Year: 2017
Journal: PLoS Pathogens
Link: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006528

Authors: Ceccherini-Silberstein F, Cento V, Cuypers L, Di Maio VC, Libin P, Lunar MM, Nevens F, Nowé A, Poljak M, Schrooten Y, Theys K, Van Laethem K, Vandamme AM
Publication Year: 2017
Journal: Infection Genetics and Evolution
Link: https://www.sciencedirect.com/science/article/pii/S1567134817301582?via%3Dihub

Resistance-associated variants (RAVs) have been shown to influence treatment response to direct-acting antivirals (DAAs) and first generation NS3/4A protease inhibitors (PIs) in particular. Interpretation of hepatitis C virus (HCV) genotypic drug resistance remains a challenge, especially in patients who previously failed DAA therapy and need to be retreated with a second DAA based regimen. Bayesian […]
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Zika virus genetic diversity and selective pressure: importance for diagnostics, vaccines and therapeutics

Authors: Abecasis A, Cuypers L, Libin P, Theys K, Vandamme AM
Publication Year: 2017
Journal: Tropical Medicine & International Health

During the last years, an increasing number of Zika virus (ZIKV) infections has been reported in Asia and America. Due to socio-environmental factors that remain to be established, this arbovirus has explosively spread to more than 60 countries worldwide. ZIKV infections can result into severe clinical manifestations, with little knowledge available to date about how […]
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Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users

Authors: Abagiu A, Abecasis A, Banica L, Jipa R, Libin P, Neaga E, Nicolae I, Otelea D, Paraschiv S, Pineda-Peña AC, Pingarilho M, Theys K
Publication Year: 2017
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185866

Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to […]
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Sub-Epidemics Explain Localized High Prevalence of Reduced Susceptibility to Rilpivirine in Treatment-Naive HIV-1-Infected Patients: Subtype and Geographic Compartmentalization of Baseline Resistance Mutations

Authors: Abecasis AB, Baele G, Camacho RJ, Gomes P, Pineda-Peña AC, Theys K, Van Laethem K, Vandamme AM
Publication Year: 2016
Journal: AIDS Research and Human Retroviruses
Link: https://www.liebertpub.com/doi/abs/10.1089/aid.2015.0095%20

The latest nonnucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine (RPV) is indicated for human immunodeficiency virus type-1 (HIV-1) patients initiating antiretroviral treatment, but the extent of genotypic RPV resistance in treatment-naive patients outside clinical trials is poorly defined. This retrospective observational study of clinical data from Belgium and Portugal evaluates genotypic information from HIV-1 drug-naive patients […]
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Zika genomics urgently need standardized and curated reference sequences

Exploring resistance pathways for first-generation NS3/4A protease inhibitors boceprevir and telaprevir using Bayesian network learning

Zika virus genetic diversity and selective pressure: importance for diagnostics, vaccines and therapeutics

Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users

Sub-Epidemics Explain Localized High Prevalence of Reduced Susceptibility to Rilpivirine in Treatment-Naive HIV-1-Infected Patients: Subtype and Geographic Compartmentalization of Baseline Resistance Mutations

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