GHTM

Global Health and Tropical Medicine

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Home / Archives for Biomedicines

Probing the Rhipicephalus bursa sialomes in potential anti-tick vaccine candidates: A reverse vaccinology approach

  • Authors: Joana Couto, Gonçalo Seixas, Christian Stutzer, Nicholas A Olivier, Christine Maritz-Olivier, Sandra Antunes, Ana Domingos
  • Publication Year: 2021
  • Journal: Biomedicines, 9(4), art 363
  • Link: https://doi.org/10.3390/biomedicines9040363

ABSTRACT In the wake of the ‘omics’ explosion of data, reverse vaccinology approaches are being applied more readily as an alternative for the discovery of candidates for next generation diagnostics and vaccines. Promising protective antigens for the control of ticks and tick-borne diseases can be discovered by mining available omics data for immunogenic epitopes. The […]
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African Trypanosomiasis: Extracellular Vesicles Shed by Trypanosoma brucei brucei Manipulate Host Mononuclear Cells

  • Authors: Tatiana Dias-Guerreiro, Joana Palma-Marques, Patrícia Mourata-Gonçalves, Graça Alexandre-Pires, Ana Valério-Bolas, Áurea Gabriel, Telmo Nunes, Wilson Antunes, Isabel Pereira da Fonseca, Marcelo Sousa-Silva, Gabriela Santos-Gomes
  • Publication Year: 2021
  • Journal: Biomedicines, 9(8), 1056
  • Link: https://doi.org/10.3390/biomedicines9081056

ABSTRACT African trypanosomiasis or sleeping sickness is a zoonotic disease caused by Trypanosoma brucei, a protozoan parasite transmitted by Glossina spp. (tsetse fly). Parasite introduction into mammal hosts triggers a succession of events, involving both innate and adaptive immunity. Macrophages (MΦ) have a key role in innate defence since they are antigen-presenting cells and have […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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