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Home / Archives for Costa M

Liaisons dangereuses: Cross-border gene flow and dispersal of insecticide resistance-associated genes in the mosquito aedes aegypti from Brazil and French Guiana

  • Autores: Salgueiro P, Restrepo-Zabaleta J, Costa M, Galardo AKR, Pinto J, Gaborit P, Guidez A, Martins AJ, Dusfour I
  • Ano de Publicação: 2019
  • Journal: Memórias do Instituto Oswaldo Cruz
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/31553370

BACKGROUND: In recent years, South America has suffered the burden of continuous high impact outbreaks of dengue, chikungunya and Zika. Aedes aegypti is the main mosquito vector of these arboviruses and its control is the only solution to reduce transmission. OBJECTIVES: In order to improve vector control it is essential to study mosquito population genetics […]
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Structure of hierridin c, synthesis of hierridins b and c, and evidence for prevalent alkylresorcinol biosynthesis in picocyanobacteria

  • Autores: Costa M, Sampaio-Dias IE, Castelo-Branco R, Scharfenstein H, Rezende de Castro R, Silva A, Schneider MPC, Araújo MJ, Martins R, Domingues VF, Nogueira F, Camões V, Vasconcelos VM, Leão PN
  • Ano de Publicação: 2019
  • Journal: Journal of Natural Products
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30715888

Small, single-celled planktonic cyanobacteria are ubiquitous in the world’s oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierridins […]
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Mosquito Akirin as a potential antigen for malaria control

  • Autores: Costa M, Custodio, de la Fuente J, Domingos A, Moreno-Cid JA, Pinheiro-Silva R, Silveira H, Villar M
  • Ano de Publicação: 2014
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/13/1/470

Recent evidences using Subolesin (SUB) and Akirin (AKR) vaccines showed a reduction in the survival and/or fertility of blood-sucking ectoparasite vectors and the infection with vector-borne pathogens. These experiments suggested the possibility of using AKR for malaria control.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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