Structure of hierridin c, synthesis of hierridins b and c, and evidence for prevalent alkylresorcinol biosynthesis in picocyanobacteria

Authors: Costa M, Sampaio-Dias IE, Castelo-Branco R, Scharfenstein H, Rezende de Castro R, Silva A, Schneider MPC, Araújo MJ, Martins R, Domingues VF, Nogueira F, Camões V, Vasconcelos VM, Leão PN
Publication Year: 2019
Journal: Journal of Natural Products
Link: https://www.ncbi.nlm.nih.gov/pubmed/30715888

Small, single-celled planktonic cyanobacteria are ubiquitous in the world’s oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierridins […]
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Single dose azithromycin for the treatment of Haemophilus ducreyi skin ulcers in Papua New Guinea

Authors: Bieb S, Gavilán S, González-Beiras C, Houinei W, Kapa A, Martins R, Mitjà O, Paru R, Sanz S, Vall-Mayans M
Publication Year: 2017
Journal: Clinical Infectious Diseases
Link: https://academic.oup.com/cid/article-abstract/65/12/2085/4083465?redirectedFrom=fulltext

BACKGROUND: Haemophilus ducreyi (HD) and Treponema pallidum subspecies pertenue (TP) are major causative agents of cutaneous ulcer (CU) in the tropics. Azithromycin is recommended to treat sexually transmitted HD infections and has good in vitro activity against HD strains from both genital and skin ulcers. We investigated the efficacy of oral single-dose azithromycin on HD-CU. […]
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Gold on paper-paper platform for Au-nanoprobe TB detection.

Authors: Baptista PV, Barquinha P, Costa MN, Fortunato E, Inácio J, Jacob JM, Martins R, Santos DS, Veigas B, Viveiros M
Journal: Lab on a Chip
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Gold+on+paper-paper+platform+for+Au-nanoprobe+TB+detection

Tuberculosis (TB) remains one of the most serious infectious diseases in the world and the rate of new cases continues to increase. The development of cheap and simple methodologies capable of identifying TB causing agents belonging to the Mycobacterium tuberculosis Complex (MTBC), at point-of-need, in particular in resource-poor countries where the main TB epidemics are observed, is of paramount relevance for the timely and effective diagnosis and management of patients.
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Structure of hierridin c, synthesis of hierridins b and c, and evidence for prevalent alkylresorcinol biosynthesis in picocyanobacteria

Single dose azithromycin for the treatment of Haemophilus ducreyi skin ulcers in Papua New Guinea

Gold on paper-paper platform for Au-nanoprobe TB detection.

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