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Home / Archives for Clinical Infectious Diseases

Etiological Characterization of the Cutaneous Ulcer Syndrome in Papua New Guinea Using Shotgun Metagenomics

  • Autores: Noguera-Julian M, González-Beiras C, Parera M, Ubals M, Kapa A, Paredes R, Mitjà O
  • Ano de Publicação: 2019
  • Journal: Clinical Infectious Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29917039

BACKGROUND: Treponema pallidum subsp pertenue and Haemophilus ducreyi are causative agents of cutaneous ulcer (CU) in yaws-endemic regions in the tropics. However, a significant proportion of CU patients remain polymerase chain reaction (PCR) negative for both bacterial agents. We aimed to identify potential additional etiological agents of CU in a yaws-endemic region. METHODS: This population-based […]
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Multiple Class i and Class II Haemophilus ducreyi Strains Cause Cutaneous Ulcers in Children on an Endemic Island

  • Autores: Abecasis A, Amick KM, Fortney KR, Gangaiah D, González-Beiras C, Grant JC, Humphreys TL, Mitjà O, Spinola SM
  • Ano de Publicação: 2018
  • Journal: Clinical Infectious Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29897409

BACKGROUND: Together with Treponema pallidum subspecies pertenue, Haemophilus ducreyi is a major cause of exudative cutaneous ulcers (CUs) in children. For H. ducreyi, both class I and class II strains, asymptomatic colonization, and environmental reservoirs have been found in endemic regions, but the epidemiology of this infection is unknown. METHODS: Based on published whole-genome sequences […]
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Single dose azithromycin for the treatment of Haemophilus ducreyi skin ulcers in Papua New Guinea

  • Autores: Bieb S, Gavilán S, González-Beiras C, Houinei W, Kapa A, Martins R, Mitjà O, Paru R, Sanz S, Vall-Mayans M
  • Ano de Publicação: 2017
  • Journal: Clinical Infectious Diseases
  • Link: https://academic.oup.com/cid/article-abstract/65/12/2085/4083465?redirectedFrom=fulltext

BACKGROUND: Haemophilus ducreyi (HD) and Treponema pallidum subspecies pertenue (TP) are major causative agents of cutaneous ulcer (CU) in the tropics. Azithromycin is recommended to treat sexually transmitted HD infections and has good in vitro activity against HD strains from both genital and skin ulcers. We investigated the efficacy of oral single-dose azithromycin on HD-CU. […]
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Metaanalysis of the Performance of a Combined Treponemal and Nontreponemal Rapid Diagnostic Test for Syphilis and Yaws

  • Autores: Aziz A, Ballard RC, Bélec L, Bottomley C, Castro A, Castro R, Causer L, Chen XS, da Luz Martins Pereira F, Guinard J, Guy R, Mabey DCW, Marks M, Mitjà O, Taleo F, Tun Y, Wangnapi R, Yin YP
  • Ano de Publicação: 2016
  • Journal: Clinical Infectious Diseases
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981758/

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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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