In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2-aniline-3-hydroxy-1.4-naphthoquinone derivatives
- Authors: Albuquerque EL, da Silva Emery F, De Andrade-Neto VF, de Sena Pereira VS, Fulco UL, Katzin AM, Lobo L, Nogueira F, Oliveira JIN
- Publication Year: 2018
- Journal: Malaria Journal
- Link: https://www.ncbi.nlm.nih.gov/pubmed/30567541
BACKGROUND: Plasmodium falciparum has shown multidrug resistance, leading to the necessity for the development of new drugs with novel targets, such as the synthesis of isoprenic precursors, which are excellent targets because the pathway is different in several steps when compared with the human host. Naphthoquinone derivatives have been described as potentially promising for the […]
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