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Home / Archives for Melo GC

Oral transmission of Trypanosoma cruzi, Brazilian Amazon

  • Authors: Santana RAG, Guerra MGVB, Sousa DR, Couceiro K, Ortiz JV, Oliveira M, Ferreira LS, Souza KR, Tavares IC, Morais RF, Silva GAV, Melo GC, Vergel GM, Albuquerque BC, Arcanjo ARL, Monteiro WM, Ferreira JMBB, Lacerda MVG, Silveira H, Guerra JAO
  • Publication Year: 2019
  • Journal: Emerging Infectious Diseases
  • Link: https://wwwnc.cdc.gov/eid/article/25/1/18-0646_article

In the Brazilian Amazon, the suspected source of infection in an outbreak of acute Chagas disease involving 10 patients was Euterpe oleracea (açaí berry) juice. Patient blood and juice samples contained Trypanosoma cruzi TcIV, indicating oral transmission of the Chagas disease agent. © 2018, Centers for Disease Control and Prevention (CDC). All rights reserved.
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Filling gaps on ivermectin knowledge: effects on the survival and reproduction of Anopheles aquasalis, a Latin American malaria vector

  • Authors: Bassat Q, Beltrán TP, Guerra M, Kobylinski KC, Lacerda MV, Lima JBP, Melo GC, Monteiro WM, Pimenta P, Rodriguez I, Sampaio VS, Silva SGM, Silveira H
  • Publication Year: 2016
  • Journal: Malaria Journal
  • Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-016-1540-y

Background Strategies designed to advance towards malaria elimination rely on the detection and treatment of infections, rather than fever, and the interruption of malaria transmission between mosquitoes and humans. Mass drug administration with anti-malarials directed at eliminating parasites in blood, either to entire populations or targeting only those with malaria infections, are considered useful strategies […]
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In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

  • Authors: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
  • Publication Year: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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