Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon

Authors: Alecrim MG, Brasil LW, Costa MR, Lacerda MV, Marques MM, Monteiro WM, Nascimento MT, Nogueira F, Reyes-Lecca RC, Santana Filho FS, Silveira H, Vieira JL
Publication Year: 2014
Journal: Antimicrobial Agents and Chemotherapy
Link: http://aac.asm.org/content/early/2013/10/22/AAC.02279-12

In Latin America, data on chloroquine (CQ)-resistant Plasmodium vivax is limited, even with the current research efforts to sustain an efficient malaria control program in all these endemic countries, where malaria still is a major public health issue.
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In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

Authors: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
Publication Year: 2013
Journal: Malaria Journal
Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
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Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon

In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

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