N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity

• Authors: Albuquerque I, Gomes A, Gomes P, Machado M, Nogueira F, Perez B, Prudencio M, Teixeira C
• Publication Year: 2014
• Journal: Chemmedchem
• Link: https://www.ncbi.nlm.nih.gov/pubmed/24474655

Plasmodium falciparum, the causative agent of the most lethal form of malaria, is becoming increasingly resistant to most available drugs. A convenient approach to combat parasite resistance is the development of analogues of classical antimalarial agents, appropriately modified in order to restore their relevance in antimalarial chemotherapy. Following this line of thought, the design, synthesis […]
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