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Home / Archives for Lopes D

Evaluation of Antiplasmodial activity of extracts and constituents from Ampelozizyphus amazonicus

  • Autores: Amaral AC, do Carmo DF, Echevarria A, Lopes D, Machado M, Rosário VE, Silva JR
  • Ano de Publicação: 2015
  • Journal: Pharmacognosy Magazine
  • Link: http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=44;spage=244;epage=250;aulast=do

Ampelozizyphus amazonicus Ducke, a plant that is widely used by the population of the Amazonian region to prevent and treat malaria, was investigated in this work, which describes, for the first time, the antiplasmodial activity of its extracts and associates this activity with its isolated constituents. Different extracts with solvents of increasing polarity (hexane, chloroform, […]
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Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola

  • Autores: Do Rosário V, Kiaco K, Lopes D, Machado M, Teixeira J
  • Ano de Publicação: 2015
  • Journal: Malaria Journal
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681156/

Drug resistance in Plasmodiumfalciparum has posed an obstacle to effective treatment and challenges many malaria control programmes in endemic areas. In Angola, until 2003, chloroquine (CQ) was used as first-line therapy for uncomplicated malaria. It was replaced initially by amodiaquine and, in 2006, by artemisinin-based combination therapy (ACT) with artemether-lumefantrine (AL, Coartem®). Efficacy study of ACT, conducted […]
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The drug transporter ABCB1 c.3435C&gt T SNP influences artemether-lumefantrine treatment outcome

  • Autores: Do Rosário V, Gil JP, Kiaco K, Lopes D, Rodrigues AS
  • Ano de Publicação: 2017
  • Journal: Malaria Journal
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/28934955

Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was […]
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Bis-alkylamineIndolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarialcytostatic and cytocidal activities

  • Autores: Charneira C, Figueiras M, Gut J, Lavrado J, Lopes D, Machado M, Moreira R, Nogueira F, Paulo A, Rosenthal PJ, Santos SA
  • Ano de Publicação: 2014
  • Journal: Journal of Medicinal Chemistry
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24673163

To get insight into the relevance of targeting hemozoin (Hz) crystals, two isomeric series, N5,N10-bis-alkylamine (2a-k) and N10,O11-bis-alkylamine (3a-k) indolo[3,2-b]quinolines, were evaluated for their in vitro activity against chloroquine (CQ)-resistant and sensitive strains of Plasmodium falciparum.
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Treatment of plasmodium chabaudi parasites with curcumin in combination with antimalarial drugs: Drug interactions and implications on the ubiquitin/proteasome system

  • Autores: Do Rosário V, Gazarini ML, Lindeza A, Lopes D, Machado M, Neto Z
  • Ano de Publicação: 2013
  • Journal: Journal of Parasitology Research
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23691276

Antimalarial drug resistance remains a major obstacle in malaria control. Evidence from Southeast Asia shows that resistance to artemisinin combination therapy (ACT) is inevitable. Ethnopharmacological studies have confirmed the efficacy of curcumin against Plasmodium spp.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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