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Home / Archives for Lopes D

A review of antimalarial plants used in traditional medicine in communities in Portuguese-speaking countries: Brazil, Mozambique, Cape Verde, Guinea-Bissau, São Tomé and Príncipe and Angola.

  • Authors: Amaral AC, Canto-Cavalheiro MM, de Moura DF, Do Rosário VE, Figueiredo P, Lopes D, Machado M, Neto Z, Ramos A de S, Silva JR
  • Journal: Memórias do Instituto Oswaldo Cruz
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=A+review+of+antimalarial+plants+used+in+traditional+medicine+in+communities+in+Portuguese-Speaking+countries%3A+Brazil%2C+Mozambique%2C+Cape+Verde%2C+Guinea-Bissau%2C+Sao+Tome+and+Principe+and+Angola

The isolation of bioactive compounds from medicinal plants, based on traditional use or ethnomedical data, is a highly promising potential approach for identifying new and effective antimalarial drug candidates.
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SLC40A1 Q248H allele frequencies and associated SLC40A1 haplotypes in three West African population samples.

  • Authors: Albuquerque D, Alvarez M, Arez AP, Lopes D, Loua KM, Manco L, Millimono TS, Nogueira F, Rath SL, Relvas L, Ribeiro ML, Trovoada Mde J, Varandas L
  • Journal: Annals of human biology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=SLC40A1+Q248H+allele+frequencies+and+associated+SLC40A1+haplotypes+in+three+West+African+population+samples.

BACKGROUND:
Ferroportin is a transmembrane protein responsible for iron export from enterocytes and macrophages. Mutation c.744G → T (Q248H), located in exon 6 of the ferroportin gene SLC40A1, is found as a polymorphism in populations of African origin. This mutation has been extensively analysed in African-Americans, but poorly studied in native African populations.
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Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

  • Authors: Afonso A, Alves AC, Castro H, Lopes D, Neto Z, Rosário VD, Tomás AM
  • Journal: Malaria Journal
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Plasmodium+chabaudi+chabaudi+malaria+parasites+can+develop+stable+resistance+to+atovaquone+with+a+mutation+in+the+cytochrome+b+gene

BACKGROUND:
Plasmodium falciparum, has developed resistance to many of the drugs in use. The recommended treatment policy is now to use drug combinations. The atovaquone-proguanil (AP) drug combination, is one of the treatment and prophylaxis options. Atovaquone (ATQ) exerts its action by inhibiting plasmodial mitochondria electron transport at the level of the cytochrome bc1 complex.
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Karavilagenin C derivatives as antimalarials.

  • Authors: Ferreira MJ, Lopes D, Molnar J, Mulhovo S, Ramalhete C, Rosário VE
  • Journal: Bioorganic & Medicinal Chemistry
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Karavilagenin+C+derivatives+as+antimalarials

Karavilagenin C (1), a cucurbitane-type triterpenoid, previously isolated from the aerial parts of Momordica balsamina, was acylated with different alkanoyl, aroyl and cinnamoyl chlorides/anydrides, yielding ten new mono or diesters, karavoates F (7) and H-P (8-16).
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Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections.

  • Authors: da Cruz FP, Ferreira MJ, Lopes D, Mulhovo S, Prudencio M, Ramalhete C, Rosário VE
  • Journal: Bioorganic & Medicinal Chemistry
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Triterpenoids+as+inhibitors+of+erythrocytic+and+liver+stages+of+Plasmodium+infections

Bioassay-guided fractionation of the methanol extract of Momordica balsamina led to the isolation of two new cucurbitane-type triterpenoids, balsaminol F (1) and balsaminoside B (2), along with the known glycosylated cucurbitacins, cucurbita-5,24-diene-3β,23(R)-diol-7-O-β-D-glucopyranoside (3) and kuguaglycoside A (4). Compound 1 was acylated yielding two new triesters, triacetylbalsaminol F (5) and tribenzoylbalsaminol F (6).
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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