Novel potent metallocenes against liver stage malaria

Authors: Cabrita E, da Cruz FP, Do Rosário VE, Gomes P, Gut J, Matos J, Moreira R, Nogueira F, Prudencio M, Rosenthal PJ
Journal: Antimicrobial Agents and Chemotherapy
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Novel+potent+metallocenes+against+liver+stage+malaria.

Novel conjugates of the antimalarial drug primaquine (compound 1) with ferrocene, named primacenes, have been synthesized and screened for their activities against blood stage and liver stage malaria in vitro and host-vector transmission in vivo.
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Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections.

Authors: da Cruz FP, Ferreira MJ, Lopes D, Mulhovo S, Prudencio M, Ramalhete C, Rosário VE
Journal: Bioorganic & Medicinal Chemistry
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Triterpenoids+as+inhibitors+of+erythrocytic+and+liver+stages+of+Plasmodium+infections

Bioassay-guided fractionation of the methanol extract of Momordica balsamina led to the isolation of two new cucurbitane-type triterpenoids, balsaminol F (1) and balsaminoside B (2), along with the known glycosylated cucurbitacins, cucurbita-5,24-diene-3β,23(R)-diol-7-O-β-D-glucopyranoside (3) and kuguaglycoside A (4). Compound 1 was acylated yielding two new triesters, triacetylbalsaminol F (5) and tribenzoylbalsaminol F (6).
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Novel potent metallocenes against liver stage malaria

Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections.

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