Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

Autores: Afonso A, Alves AC, Castro H, Lopes D, Neto Z, Rosário VD, Tomás AM
Journal: Malaria Journal
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Plasmodium+chabaudi+chabaudi+malaria+parasites+can+develop+stable+resistance+to+atovaquone+with+a+mutation+in+the+cytochrome+b+gene

BACKGROUND:
Plasmodium falciparum, has developed resistance to many of the drugs in use. The recommended treatment policy is now to use drug combinations. The atovaquone-proguanil (AP) drug combination, is one of the treatment and prophylaxis options. Atovaquone (ATQ) exerts its action by inhibiting plasmodial mitochondria electron transport at the level of the cytochrome bc1 complex.
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Quindolone derivatives, designed to target the malaria parasite digestive vacuole and heme detoxification pathway, have been synthesized by reaction with 2-chloro-N,N-diethylethanamine. This reaction gave N,O-, N,N- and O-alkylated products containing one or two basic side-chains. The compounds were evaluated for antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum W2 strain and for cytotoxicity in HepG2 A16 […]
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Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

Bis-alkylamine quindolone derivatives as new antimalarial leads

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