- Autores: Do Rosário V, Gil JP, Kiaco K, Lopes D, Rodrigues AS
- Ano de Publicação: 2017
- Journal: Malaria Journal
- Link: https://www.ncbi.nlm.nih.gov/pubmed/28934955
Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.