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Home / Publications / The drug transporter ABCB1 c.3435C&gt T SNP influences artemether-lumefantrine treatment outcome

The drug transporter ABCB1 c.3435C&gt T SNP influences artemether-lumefantrine treatment outcome

  • Authors: Do Rosário V, Gil JP, Kiaco K, Lopes D, Rodrigues AS
  • Publication Year: 2017
  • Journal: Malaria Journal
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/28934955

Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was found among the recurrent infection-free patients (p < 0.01), suggesting a role for this transporter in AL inter-individual performance.

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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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