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Home / Archives for Kiaco K

Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola

  • Autores: Do Rosário V, Kiaco K, Lopes D, Machado M, Teixeira J
  • Ano de Publicação: 2015
  • Journal: Malaria Journal
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681156/

Drug resistance in Plasmodiumfalciparum has posed an obstacle to effective treatment and challenges many malaria control programmes in endemic areas. In Angola, until 2003, chloroquine (CQ) was used as first-line therapy for uncomplicated malaria. It was replaced initially by amodiaquine and, in 2006, by artemisinin-based combination therapy (ACT) with artemether-lumefantrine (AL, Coartem®). Efficacy study of ACT, conducted […]
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The drug transporter ABCB1 c.3435C&gt T SNP influences artemether-lumefantrine treatment outcome

  • Autores: Do Rosário V, Gil JP, Kiaco K, Lopes D, Rodrigues AS
  • Ano de Publicação: 2017
  • Journal: Malaria Journal
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/28934955

Malaria treatment performance is potentially influenced by pharmacogenetic factors. This study reports an association study between the ABCB1 c.3435C>T, CYP3A4*1B (g.-392A>G), CYP3A5*3 (g.6986A>G) SNPs and artemether + lumefantrine treatment outcome in 103 uncomplicated malaria patients from Angola. No significant associations with the CYP3A4*1B and CYP3A5*3 were observed, while a significant predominance of the ABCB1 c.3435CC genotype was […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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