Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 sub-subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium

Authors: Vinken L, Fransen K, Cuypers L, Alexiev I, Balotta C, Debaisieux L, Seguin-Devaux C, García Ribas S, Gomes P, Incardona F, Kaiser R, Ruelle J, Sayan M, Paraschiv S, Paredes R, Peeters M, Sönnerborg A, Vancutsem E, Vandamme AM, Van den Wijngaert S, Van Ranst M, Verhofstede C, Stadler T, Lemey P, Van Laethem K
Publication Year: 2019
Journal: Frontiers in Microbiology
Link: https://www.ncbi.nlm.nih.gov/pubmed/30972053

Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this […]
Read More

Genome Detective: an automated system for virus identification from high-throughput sequencing data

Authors: Vilsker M, Moosa Y, Nooij S, Fonseca V, Ghysens Y, Dumon K, Pauwels R, Alcantara LC, Vanden Eynden E, Vandamme AM, Deforche K, De Oliveira T
Publication Year: 2019
Journal: Bioinformatics
Link: https://www.ncbi.nlm.nih.gov/pubmed/30124794

Genome Detective is an easy to use web-based software application that assembles the genomes of viruses quickly and accurately. The application uses a novel alignment method that constructs genomes by reference-based linking of de novo contigs by combining amino-acids and nucleotide scores. The software was optimized using synthetic datasets to represent the great diversity of […]
Read More

Transmission phenotype of mycobacterium tuberculosis strains is mechanistically linked to induction of distinct pulmonary pathology

Authors: Verma S, Bhatt K, Lovey A, Ribeiro-Rodrigues R, Durbin J, Jones-López EC, Palaci M, Vinhas SA, Alland D, Dietze R, Ellner JJ, Salgame P
Publication Year: 2019
Journal: PLoS Pathogens
Link: https://www.ncbi.nlm.nih.gov/pubmed/30840702

In a study of household contacts (HHC), households were categorized into High (HT) and Low (LT) transmission groups based on the proportion of HHC with a positive tuberculin skin test. The Mycobacterium tuberculosis (Mtb) strains from HT and LT index cases of the households were designated Mtb-HT and Mtb-LT, respectively. We found that C3HeB/FeJ mice […]
Read More

Trypanosoma brucei interaction with host: Mechanism of VSG release as target for drug discovery for african trypanosomiasis

Authors: Moreno CJG, Temporão A, Torres T, Silva MS
Publication Year: 2019
Journal: International Journal of Molecular Sciences
Link: https://www.ncbi.nlm.nih.gov/pubmed/30934540

The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular and presents a robust mechanism of antigenic variation that allows the persistence of infection. […]
Read More

First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation

Authors: Auerswald H, de Jesus A, Seixas G, Nazareth T, In S, Mao S, Duong V, Silva AC, Raul R, Dussart P, Sousa CA
Publication Year: 2019
Journal: Parasites & Vectors
Link: https://www.ncbi.nlm.nih.gov/pubmed/30867031

BACKGROUND: In 2012, the first dengue virus outbreak was reported on the Portuguese island of Madeira with 1080 confirmed cases. Dengue virus of serotype 1 (DENV-1), probably imported from Venezuela, caused this outbreak with autochthonous transmission by invasive Aedes aegypti mosquitoes. RESULTS: We investigated the seroprevalence among the population on Madeira Island four years after […]
Read More

Earlier initiation of antiretroviral treatment coincides with an initial control of the HIV-1 sub-subtype F1 outbreak among men-having-sex-with-men in Flanders, Belgium

Genome Detective: an automated system for virus identification from high-throughput sequencing data

Transmission phenotype of mycobacterium tuberculosis strains is mechanistically linked to induction of distinct pulmonary pathology

Trypanosoma brucei interaction with host: Mechanism of VSG release as target for drug discovery for african trypanosomiasis

First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation

About GHTM

Contacts

Subscribe Newsletter