GHTM

Global Health and Tropical Medicine

Home / Archives for Tatyana Almeida Tavella

Targeting malaria protein kinases

CHAPTER 7 OF THE BOOK «PROTEIN KINASES IN DRUG DISCOVERY»   ABSTRACT Malaria is one of the most impacting public health problems in tropical and subtropical areas of the globe, with approximately 200 million cases worldwide annually. In the absence of an effective vaccine, rapid treatment is vital for effective malaria control. However, parasite resistance […]
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Yeast-based high-throughput screens for discovery of kinase inhibitors for neglected diseases

CHAPTER 8 OF THE BOOK «PROTEIN KINASES IN DRUG DISCOVERY»   ABSTRACT The discovery and development of a new drug is a complex, time consuming and costly process that typically takes over 10 years and costs around 1 billion dollars from bench to market. This scenario makes the discovery of novel drugs targeting neglected tropical […]
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Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity

ABSTRACT Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, including the malaria parasite, Plasmodium falciparum (Pf). Herein, using chemical genomic profiling (CGP), we found that violacein affects protein […]
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GHTM is a R&D Unit that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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