Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene

Authors: Chapadense F, Machado RLD, Ventura AMRDS, Áreas A, Machado RB, Viana GR, Zalis MG, de Castro AM, Cravo P
Publication Year: 2019
Journal: Revista da Sociedade Brasileira de Medicina Tropical
Link: https://www.ncbi.nlm.nih.gov/pubmed/30810653

INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. RESULTS: We identified 1 K189T substitution located outside the propeller domain of the […]
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In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate

Authors: Cravo P, Machado RB, Leite JA, Leda T, Suwanarusk R, Bittencourt N, Albrecht L, Judice C, Lopes SCP, Lacerda MVG, Ferreira MU, Soares IS, Goh YS, Bargieri DY, Nosten F, Russell B, Rénia L, Costa FTM
Publication Year: 2018
Journal: Malaria Journal
Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-017-2144-x%20

BACKGROUND: Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated. RESULTS: Detailed epitope mapping of MAEBL […]
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Modern approaches to accelerate discovery of new antischistosomal drugs

Authors: Andrade CH, Cravo P, Machado RB, Muratov E, Neves BJ
Publication Year: 2016
Journal: Expert Opinion on Drug Discovery
Link: https://www.tandfonline.com/doi/abs/10.1080/17460441.2016.1178230?journalCode=iedc20

INTRODUCTION: The almost exclusive use of only praziquantel for the treatment of schistosomiasis has raised concerns about the possible emergence of drug-resistant schistosomes. Consequently, there is an urgent need for new antischistosomal drugs. The identification of leads and the generation of high quality data are crucial steps in the early stages of schistosome drug discovery […]
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Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene

In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate

Modern approaches to accelerate discovery of new antischistosomal drugs

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