Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene
- Authors: Chapadense F, Machado RLD, Ventura AMRDS, Áreas A, Machado RB, Viana GR, Zalis MG, de Castro AM, Cravo P
- Publication Year: 2019
- Journal: Revista da Sociedade Brasileira de Medicina Tropical
- Link: https://www.ncbi.nlm.nih.gov/pubmed/30810653
INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. RESULTS: We identified 1 K189T substitution located outside the propeller domain of the […]
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