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Global Health and Tropical Medicine

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Dog hepatocytes are key effector cells in the liver innate immune response to Leishmania infantum

Hepatocytes constitute the majority of hepatic cells, and play a key role in controlling systemic innate immunity, via pattern-recognition receptors (PRRs) and by synthesizing complement and acute phase proteins. Leishmania infantum, a protozoan parasite that causes human and canine leishmaniasis, infects liver by establishing inside the Kupffer cells. The current study proposes the elucidation of […]
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Canine neutrophils cooperate with macrophages in the early stages of Leishmania infantum in vitro infection

Leishmania infantum is the aetiological agent of human visceral leishmaniasis and canine leishmaniasis, both systemic and potentially fatal diseases. Polymorphonuclear neutrophils (PMN) are the first cells to phagocyte this parasite at the inoculation site, but macrophages (MØ) are the definitive host cells, ensuring parasite replication. The interaction between dog MØ, PMN and L infantum promastigotes was […]
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Canine neutrophils activate effector mechanisms in response to Leishmania infantum

Canine leishmaniosis caused by L. infantum is a severe zoonotic disease. Although macrophages are the definitive host cells, neutrophils are the first cells to encounter the parasite soon after its inoculation in the dermis by the phlebotomine vector. To study the interaction of dog neutrophils and L. infantum promastigotes, blood neutrophils were isolated from healthy […]
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Introdution

This book addresses a notable gap in the knowledge of Portuguese colonial administration and the policies implemented in the main territories of its “third” African empire: Angola, Mozambique and Guinea. In recent years, the question of colonial taxation has become a topic in the academic debate on colonial empires and has led to a comparative, […]
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Administration and Taxation in former Portuguese Africa: 1900-1945

This book addresses a notable gap in the knowledge of Portuguese colonial administration and the policies implemented in the main territories of its “third” African empire: Angola, Mozambique and Guinea. In recent years, the question of colonial taxation has become a topic in the academic debate on colonial empires and has led to a comparative, […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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