Dog hepatocytes are key effector cells in the liver innate immune response to Leishmania infantum

Hepatocytes constitute the majority of hepatic cells, and play a key role in controlling systemic innate immunity, via pattern-recognition receptors (PRRs) and by synthesizing complement and acute phase proteins. Leishmania infantum, a protozoan parasite that causes human and canine leishmaniasis, infects liver by establishing inside the Kupffer cells. The current study proposes the elucidation of […]
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Leishmania infantum exerts immunomodulation in canine Kupffer cells reverted by meglumine antimoniate

Authors: Alexandre-Pires G, Alves-Azevedo R, de Jesus J, Ligeiro D, Lopes-Ventura S, Pereira da Fonseca I, Pereira MA, Rafael-Fernandes M, Rodrigues A, Santos M, Santos-Gomes G, Santos-Mateus D, Tomás AM, Valério-Bolas A
Publication Year: 2017
Journal: Comparative Immunology Microbiology and Infectious Diseases
Link: https://www.sciencedirect.com/science/article/pii/S0147957117300863?via%3Dihub

Kupffer cells (KC) are the liver macrophage population that resides in the hepatic sinusoids and efficiently phagocyte pathogens by establishing an intimate contact with circulating blood. KC constitute the liver host cells in Leishmania infection, nevertheless little is described about their role, apart from their notable contribution in granulomatous inflammation. The present study aims to […]
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Dog hepatocytes are key effector cells in the liver innate immune response to Leishmania infantum

Leishmania infantum exerts immunomodulation in canine Kupffer cells reverted by meglumine antimoniate

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