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Home / Archives for Pereira MA

Dog hepatocytes are key effector cells in the liver innate immune response to Leishmania infantum

  • Autores: Rodrigues A, Alexandre-Pires G, Valério-Bolas A, Santos-Mateus D, Rafael-Fernandes M, Pereira MA, Ligeiro D, Nunes T, Alves-Azevedo R, Lopes-Ventura S, Santos M, Tomás AM, Pereira da Fonseca I, Santos-Gomes G
  • Ano de Publicação: 2019
  • Journal: Parasitology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30561285

Hepatocytes constitute the majority of hepatic cells, and play a key role in controlling systemic innate immunity, via pattern-recognition receptors (PRRs) and by synthesizing complement and acute phase proteins. Leishmania infantum, a protozoan parasite that causes human and canine leishmaniasis, infects liver by establishing inside the Kupffer cells. The current study proposes the elucidation of […]
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Canine neutrophils cooperate with macrophages in the early stages of Leishmania infantum in vitro infection

  • Autores: Pereira MA, Alexandre-Pires G, Câmara M, Santos M, Martins C, Rodrigues A, Adriana J, Passero LFD, Pereira da Fonseca I, Santos-Gomes G
  • Ano de Publicação: 2019
  • Journal: Parasite Immunology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30735568

Leishmania infantum is the aetiological agent of human visceral leishmaniasis and canine leishmaniasis, both systemic and potentially fatal diseases. Polymorphonuclear neutrophils (PMN) are the first cells to phagocyte this parasite at the inoculation site, but macrophages (MØ) are the definitive host cells, ensuring parasite replication. The interaction between dog MØ, PMN and L infantum promastigotes was […]
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Leishmania infantum antigens modulate memory cell subsets of liver resident T lymphocyte

  • Autores: Alexandre-Pires G, Claro M, Martins C, Pereira da Fonseca I, Pereira MA, Rafael-Fernandes M, Rodrigues A, Santos-Gomes G, Santos-Mateus D, Tomás AM, Valério-Bolas A
  • Ano de Publicação: 2017
  • Journal: Immunobiology
  • Link: https://www.sciencedirect.com/science/article/pii/S0171298516303564?via%3Dihub

In the recent years, the liver has been recognized as an important immune organ with major regulatory functions and immune memory, adding to the well-described vital metabolic functions. There are evidences from experimental infections performed with visceral Leishmania species that immune responses to parasite infection can be organ-specific. The liver is the compartment of acute […]
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Leishmania infantum exerts immunomodulation in canine Kupffer cells reverted by meglumine antimoniate

  • Autores: Alexandre-Pires G, Alves-Azevedo R, de Jesus J, Ligeiro D, Lopes-Ventura S, Pereira da Fonseca I, Pereira MA, Rafael-Fernandes M, Rodrigues A, Santos M, Santos-Gomes G, Santos-Mateus D, Tomás AM, Valério-Bolas A
  • Ano de Publicação: 2017
  • Journal: Comparative Immunology Microbiology and Infectious Diseases
  • Link: https://www.sciencedirect.com/science/article/pii/S0147957117300863?via%3Dihub

Kupffer cells (KC) are the liver macrophage population that resides in the hepatic sinusoids and efficiently phagocyte pathogens by establishing an intimate contact with circulating blood. KC constitute the liver host cells in Leishmania infection, nevertheless little is described about their role, apart from their notable contribution in granulomatous inflammation. The present study aims to […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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