GHTM

Global Health and Tropical Medicine

  • GHTM
    • About GHTM
    • Governance
    • Impact
    • Members
      • Population health, policies and services
        • PPS PhD members
        • PPS non PhD members
      • TB, HIV and opportunistic diseases and pathogens
        • THOP PhD members
        • THOP non PhD members
      • Vector-borne diseases
        • VBD PhD members
        • VBD non PhD members
      • Individual Health Care
        • IHC PhD members
        • IHC non PhD members
      • Tech & Admin support
    • Scientific Advisory Board
  • Research
    • Cross-cutting issues
      • Global Pathogen Dispersion and Population Mobility
      • Drug Discovery and Drug Resistance
      • Diagnostics
      • Public Health Information
      • Fair Research Partnerships
    • Research Groups
      • PPS – Population health, policies and services
      • THOP – TB, HIV and opportunistic diseases and pathogens
      • VBD – Vector borne diseases
      • IHC – Individual health care
    • Research in numbers
      • 2023
      • 2022
      • 2021
      • 2020
      • 2019
      • 2018
      • 2017
    • Projects
      • Ongoing Projects
      • Completed Projects
  • Outreach
    • Events
    • News
    • Policy Support & Community Outreach
  • Publications
    • 2024
    • 2023
    • 2022
    • 2021
    • 2020
    • 2019
    • 2018
    • 2017
    • 2016
    • 2015
  • Capacity Building
    • Education
      • Master Theses
      • PhD Theses
    • International
  • Infrastructures
  • Networks & Partnerships
  • Reports
    • GHTM
    • Scientific Advisory Board
    • FCT
Home / Archives for Valério-Bolas A

Dog hepatocytes are key effector cells in the liver innate immune response to Leishmania infantum

  • Authors: Rodrigues A, Alexandre-Pires G, Valério-Bolas A, Santos-Mateus D, Rafael-Fernandes M, Pereira MA, Ligeiro D, Nunes T, Alves-Azevedo R, Lopes-Ventura S, Santos M, Tomás AM, Pereira da Fonseca I, Santos-Gomes G
  • Publication Year: 2019
  • Journal: Parasitology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30561285

Hepatocytes constitute the majority of hepatic cells, and play a key role in controlling systemic innate immunity, via pattern-recognition receptors (PRRs) and by synthesizing complement and acute phase proteins. Leishmania infantum, a protozoan parasite that causes human and canine leishmaniasis, infects liver by establishing inside the Kupffer cells. The current study proposes the elucidation of […]
Read More

Intracellular and extracellular effector activity of mouse neutrophils in response to cutaneous and visceral Leishmania parasites

  • Authors: Valério-Bolas A, Pereira M, Alexandre-Pires G, Santos-Mateus D, Rodrigues A, Rafael-Fernandes M, Gabriel A, Passero F, Santos-Gomes G
  • Publication Year: 2019
  • Journal: Cellular Immunology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30424873

Neutrophils are short-lived phagocytic cells equipped with several receptors for pathogen recognition and phagocytosis and have intracellular and extracellular effector mechanisms that can inactivate pathogens. Leishmaniases are diseases caused by different species of Leishmania that mainly afflicts poorer populations of tropical and subtropical regions and immunocompromised individuals. Thus, the present study aims to investigate the […]
Read More

Canine neutrophils activate effector mechanisms in response to Leishmania infantum

  • Authors: Alexandre-Pires G, da Fonseca IP, Martins C, Passero F, Pereira M, Rocha H, Rodrigues A, Santos A, Santos M, Santos-Gomes G, Santos-Mateus D, Tomas A, Valério-Bolas A
  • Publication Year: 2017
  • Journal: Veterinary Parasitology
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/29173534

Canine leishmaniosis caused by L. infantum is a severe zoonotic disease. Although macrophages are the definitive host cells, neutrophils are the first cells to encounter the parasite soon after its inoculation in the dermis by the phlebotomine vector. To study the interaction of dog neutrophils and L. infantum promastigotes, blood neutrophils were isolated from healthy […]
Read More

The battle between Leishmania and the host immune system at a glance

  • Authors: Laurenti MD, Passero F, Pereira M, Rodrigues A, Santos-Gomes G, Santos-Mateus D, Silva-Pedrosa R, Valério-Bolas A
  • Publication Year: 2016
  • Journal: International Trends in Immunity
  • Link: https://webcache.googleusercontent.com/search?q=cache:GZtE3sdIh7sJ:https://www.researchgate.net/profile/Felipe_Passero/publication/297453064_The_Battle_between_Leishmania_and_the_Host_Immune_System_at_a_Glance/links/56df19c708aee77a15fcf238/The-Battle-between-Leishmania-and-the-Host-Immune-System-at-a-Glance.pdf+&cd=1&hl=en&ct=clnk&gl=pt

Leishmaniasis is a neglected parasitic disease whose diverse clinical manifestations are dependent on the interrelations between intrinsic and extrinsic factors. The infecting species of Leishmania, the parasite’s ability to evade mammal immune response and the host genetic background seems to pre-determine the degree of resistance and sensitivity to infection, regulating the disease outcome. The introduction […]
Read More

Successful treatment of feline leishmaniosis using an association of allopurinol and N-methyl-glucamine antimoniate

  • Authors: Basso MA, Carreira LM, Duarte A, Fonseca Pereira I, Gomes L, Marques C, Pissarra H, Santos M, Santos-Gomes G, Tavares L, Valério-Bolas A
  • Publication Year: 2016
  • Journal: Journal of Feline Medicine and Surgery Open Reports
  • Link: http://journals.sagepub.com/doi/full/10.1177/2055116916630002

This work describes the diagnosis and successful treatment of a 2-year-old domestic cat infected with Leishmania species and presenting fever, and ulcerative and nodular skin lesions after being treated for pyodermatitis for 1 year without clinical improvement. After anamnesis the cat was submitted to a complete clinical examination. Blood was collected for determination of haematological […]
Read More

  • 1
  • 2
  • Next Page »

About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

Contacts

Rua da Junqueira, 100
1349-008 Lisboa
Portugal

+351 213 652 600

  • E-mail
  • Facebook
  • LinkedIn
  • Twitter
  • YouTube

Map

  • Events
  • Research Groups
  • Cross-cutting issues
© Copyright 2025 IHMT-UNL All Rights Reserved.
  • Universidade Nova de Lisboa
  • Fundação para a Ciência e a Tecnologia

    UIDB/04413/2020
    UIDP/04413/2020

We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it.Ok