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Home / Publicações / Successful treatment of feline leishmaniosis using an association of allopurinol and N-methyl-glucamine antimoniate

Successful treatment of feline leishmaniosis using an association of allopurinol and N-methyl-glucamine antimoniate

  • Autores: Basso MA, Carreira LM, Duarte A, Fonseca Pereira I, Gomes L, Marques C, Pissarra H, Santos M, Santos-Gomes G, Tavares L, Valério-Bolas A
  • Ano de Publicação: 2016
  • Journal: Journal of Feline Medicine and Surgery Open Reports
  • Link: http://journals.sagepub.com/doi/full/10.1177/2055116916630002

This work describes the diagnosis and successful treatment of a 2-year-old domestic cat infected with Leishmania species and presenting fever, and ulcerative and nodular skin lesions after being treated for pyodermatitis for 1 year without clinical improvement. After anamnesis the cat was submitted to a complete clinical examination. Blood was collected for determination of haematological and biochemical parameters, detection of feline leukaemia virus (FeLV), feline immunodeficiency virus (FIV), feline coronavirus (FCoV) and Leishmania amastigotes. Fine-needle aspiration puncture from the skin nodules was also performed. After definitive diagnosis the animal was treated and followed up over a 2 year period. The animal tested negative for FIV-specific antibodies, FeLV antigen and feline coronavirus RNA. Leishmania amastigotes in the skin nodules were confirmed by cytology and molecular diagnosis. Treatment was initiated with allopurinol, resulting in a slight clinical improvement. Thus, N-methyl-glucamine antimoniate was added and administered for 30 days, with complete closure of the ulcerative lesions in the hindlimbs requiring a surgical approach. Close monitoring of the patient in the following 24 months indicated that combined therapy was safe and clinical cure was achieved without further relapses or side effects.

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GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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