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Home / Archives for Valério-Bolas A

Leishmania infantum antigens modulate memory cell subsets of liver resident T lymphocyte

  • Autores: Alexandre-Pires G, Claro M, Martins C, Pereira da Fonseca I, Pereira MA, Rafael-Fernandes M, Rodrigues A, Santos-Gomes G, Santos-Mateus D, Tomás AM, Valério-Bolas A
  • Ano de Publicação: 2017
  • Journal: Immunobiology
  • Link: https://www.sciencedirect.com/science/article/pii/S0171298516303564?via%3Dihub

In the recent years, the liver has been recognized as an important immune organ with major regulatory functions and immune memory, adding to the well-described vital metabolic functions. There are evidences from experimental infections performed with visceral Leishmania species that immune responses to parasite infection can be organ-specific. The liver is the compartment of acute […]
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Leishmania infantum exerts immunomodulation in canine Kupffer cells reverted by meglumine antimoniate

  • Autores: Alexandre-Pires G, Alves-Azevedo R, de Jesus J, Ligeiro D, Lopes-Ventura S, Pereira da Fonseca I, Pereira MA, Rafael-Fernandes M, Rodrigues A, Santos M, Santos-Gomes G, Santos-Mateus D, Tomás AM, Valério-Bolas A
  • Ano de Publicação: 2017
  • Journal: Comparative Immunology Microbiology and Infectious Diseases
  • Link: https://www.sciencedirect.com/science/article/pii/S0147957117300863?via%3Dihub

Kupffer cells (KC) are the liver macrophage population that resides in the hepatic sinusoids and efficiently phagocyte pathogens by establishing an intimate contact with circulating blood. KC constitute the liver host cells in Leishmania infection, nevertheless little is described about their role, apart from their notable contribution in granulomatous inflammation. The present study aims to […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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