Intracellular and extracellular effector activity of mouse neutrophils in response to cutaneous and visceral Leishmania parasites

Authors: Valério-Bolas A, Pereira M, Alexandre-Pires G, Santos-Mateus D, Rodrigues A, Rafael-Fernandes M, Gabriel A, Passero F, Santos-Gomes G
Publication Year: 2019
Journal: Cellular Immunology
Link: https://www.ncbi.nlm.nih.gov/pubmed/30424873

Neutrophils are short-lived phagocytic cells equipped with several receptors for pathogen recognition and phagocytosis and have intracellular and extracellular effector mechanisms that can inactivate pathogens. Leishmaniases are diseases caused by different species of Leishmania that mainly afflicts poorer populations of tropical and subtropical regions and immunocompromised individuals. Thus, the present study aims to investigate the […]
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Canine neutrophils activate effector mechanisms in response to Leishmania infantum

Authors: Alexandre-Pires G, da Fonseca IP, Martins C, Passero F, Pereira M, Rocha H, Rodrigues A, Santos A, Santos M, Santos-Gomes G, Santos-Mateus D, Tomas A, Valério-Bolas A
Publication Year: 2017
Journal: Veterinary Parasitology
Link: https://www.ncbi.nlm.nih.gov/pubmed/29173534

Canine leishmaniosis caused by L. infantum is a severe zoonotic disease. Although macrophages are the definitive host cells, neutrophils are the first cells to encounter the parasite soon after its inoculation in the dermis by the phlebotomine vector. To study the interaction of dog neutrophils and L. infantum promastigotes, blood neutrophils were isolated from healthy […]
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The battle between Leishmania and the host immune system at a glance

Leishmaniasis is a neglected parasitic disease whose diverse clinical manifestations are dependent on the interrelations between intrinsic and extrinsic factors. The infecting species of Leishmania, the parasite’s ability to evade mammal immune response and the host genetic background seems to pre-determine the degree of resistance and sensitivity to infection, regulating the disease outcome. The introduction […]
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Intracellular and extracellular effector activity of mouse neutrophils in response to cutaneous and visceral Leishmania parasites

Canine neutrophils activate effector mechanisms in response to Leishmania infantum

The battle between Leishmania and the host immune system at a glance

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