Canine neutrophils cooperate with macrophages in the early stages of Leishmania infantum in vitro infection
- Authors: Pereira MA, Alexandre-Pires G, Câmara M, Santos M, Martins C, Rodrigues A, Adriana J, Passero LFD, Pereira da Fonseca I, Santos-Gomes G
- Publication Year: 2019
- Journal: Parasite Immunology
- Link: https://www.ncbi.nlm.nih.gov/pubmed/30735568
Leishmania infantum is the aetiological agent of human visceral leishmaniasis and canine leishmaniasis, both systemic and potentially fatal diseases. Polymorphonuclear neutrophils (PMN) are the first cells to phagocyte this parasite at the inoculation site, but macrophages (MØ) are the definitive host cells, ensuring parasite replication. The interaction between dog MØ, PMN and L infantum promastigotes was […]
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