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Global Health and Tropical Medicine

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Successful treatment of feline leishmaniosis using an association of allopurinol and N-methyl-glucamine antimoniate

This work describes the diagnosis and successful treatment of a 2-year-old domestic cat infected with Leishmania species and presenting fever, and ulcerative and nodular skin lesions after being treated for pyodermatitis for 1 year without clinical improvement. After anamnesis the cat was submitted to a complete clinical examination. Blood was collected for determination of haematological […]
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Implementation of a monitoring and evaluation system at the federal level: the e-car case in the Department of Monitoring and Evaluation of the Integrated Health System (SUS)

The implementation analysis of the monitoring and evaluation system for the strategic and operational actions management of the Ministry of Health, named Control, Monitoring and Evaluation of Results System (e-CAR), consisted of a case study with a qualitative research approach, using documentary analysis, participant observation and open interviews. The evolution of the system implementation, under […]
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Guidelines for the Detection of Babesia and Theileria Parasites

The genera Babesia and Theileria (phylum Apicomplexa, order Piroplasmida) are mainly transmitted by Ixodid ticks in which the sexual part of their life cycle followed by sporogony takes place. They include protozoan parasites that infect erythrocytes of a variety of vertebrate hosts, including domestic and wild animals, with some Babesia spp. also infecting humans. Babesia […]
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A field evaluation of an isothermal DNA amplification assay for the detection of Theileria annulata infection in cattle

A loop-mediated isothermal amplification (LAMP) assay was evaluated for the detection of Theileria annulata infection in cattle. The results were compared with a real-time PCR used for the quantification of T. annulata parasitaemia. One hundred bovine blood samples from 16 cattle farms were tested with LAMP and real-time PCR, with T. annulata DNA being detected in 66% […]
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Leishmania infantum exerts immunomodulation in canine Kupffer cells reverted by meglumine antimoniate

Kupffer cells (KC) are the liver macrophage population that resides in the hepatic sinusoids and efficiently phagocyte pathogens by establishing an intimate contact with circulating blood. KC constitute the liver host cells in Leishmania infection, nevertheless little is described about their role, apart from their notable contribution in granulomatous inflammation. The present study aims to […]
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GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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