Characterization of Envelope Surface Glycoprotein from HIV-2 Primary Isolates with Different Coreceptor Usage Profile

The main goal of this work was to identify molecular signatures in envelope surface glycoprotein that may be correlated with coreceptor usage by different human immunodeficiency virus (HIV)-2 strains. From inspection of aligned HIV-2 sequences, we verified that V1/V2 region showed the highest degree of amino acid sequence heterogeneity, including polymorphisms in N-linked glycosylation sites, […]
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Global rise in emerging alien species results from increased accessibility of new source pools

Our ability to predict the identity of future invasive alien species is largely based upon knowledge of prior invasion history. Emerging alien species-those never encountered as aliens before-therefore pose a significant challenge to biosecurity interventions worldwide. Understanding their temporal trends, origins, and the drivers of their spread is pivotal to improving prevention and risk assessment […]
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QSAR-driven design and discovery of novel compounds with antiplasmodial and transmission blocking activities

Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved resistance to all current antimalarial drugs, urging for the discovery of new effective compounds. Given that the inhibition of […]
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Sesquiterpenes effects on DNA of Schistosoma mansoni after in vivo treatment

Schistosomiasis is a chronic Neglected Tropical Disease that can be debilitating, particularly children, of tropical and subtropical regions presenting an enormous global health and economic burden. Notoriously for over 30 years, the praziquantel (PZQ) is the only drug used for treatment of disease. For this reason, the search for new schistosomicidal drugs is a priority. […]
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Menthol and Menthone Associated with Acetylsalicylic Acid and Their Relation to the Hepatic Fibrosis in Schistosoma mansoni Infected Mice

Schistosomiasis is an important parasitic disease caused by Schistosoma mansoni, an intravascular trematode. Schistosomiasis treatment is limited to just one drug, Praziquantel (PZQ). Thus, studies on new antischistosomal compounds are of fundamental importance to disease control. Here we report on the effects of Mentha piperita L. compounds – menthol and menthone – in association with acetylsalicylic acid (ASA) […]
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Characterization of Envelope Surface Glycoprotein from HIV-2 Primary Isolates with Different Coreceptor Usage Profile

Global rise in emerging alien species results from increased accessibility of new source pools

QSAR-driven design and discovery of novel compounds with antiplasmodial and transmission blocking activities

Sesquiterpenes effects on DNA of Schistosoma mansoni after in vivo treatment

Menthol and Menthone Associated with Acetylsalicylic Acid and Their Relation to the Hepatic Fibrosis in Schistosoma mansoni Infected Mice

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