GHTM

Global Health and Tropical Medicine

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Home / Archives for PLoS One

Visualisation of Leishmania donovani fluorescent hybrids during early stage development in the sand fly vector.

  • Authors: Lewis MD, Maurício I, Miles MA, Sadlova J, Seblova V, Volf P, Yeo M
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Visualisation+of+Leishmania+donovani+fluorescent+hybrids+during+early+stage+development+in+the+sand+fly+vector

BACKGROUND:
The Leishmania protozoan parasites cause devastating human diseases. Leishmania have been considered to replicate clonally, without genetic exchange. However, an accumulation of evidence indicates that there are inter-specific and intra-specific hybrids among natural populations.
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Origin and Epidemiological History of HIV-1 CRF14_BG

  • Authors: Abecasis AB, Barroso H, Bártolo I, Borrego P, Camacho R, Gomes P, McCutchan F, Taveira N
  • Journal: PLoS One
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=26&SID=P2WA5hwy5j35Sqjoq2z&page=1&doc=1

Background: CRF14_BG isolates, originally found in Spain, are characterized by CXCR4 tropism and rapid disease progression. This study aimed to identify the origin of CRF14_BG and reconstruct its epidemiological history based on new isolates from Portugal.
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Development of mathematical models for the analysis of hepatitis delta virus viral dynamics

  • Authors: Cunha C, de Sousa BC
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/20862328

BACKGROUND:
Mathematical models have shown to be extremely helpful in understanding the dynamics of different virus diseases, including hepatitis B. Hepatitis D virus (HDV) is a satellite virus of the hepatitis B virus (HBV).
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Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.

  • Authors: Baptista MC, Barbas JP, Cantante C, Fontes CA, Gonçalves J, Horta AE, Marques CC, Mesquita P, Pereira RM, Pimenta J, Prates JA, Santos A, Santos P, Viegas A
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Is+prnt+a+Pseudogene%3F+Identification+of+Ram+Prt+in+Testis+and+Ejaculated+Spermatozoa.

A hallmark of prion diseases or transmissible spongiform encephalopaties is the conversion of the cellular prion protein (PrP(C)), expressed by the prion gene (prnp), into an abnormally folded isoform (PrP(Sc)) with amyloid-like features that causes scrapie in sheep among other diseases. prnp together with prnd (which encodes a prion-like protein designated as Doppel), and prnt (that encodes the prion protein testis specific–Prt) with sprn (shadow of prion protein gene, that encodes Shadoo or Sho) genes, constitute the “prion gene complex”.
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Clinical Evaluation of Rega 8: An Updated Genotypic Interpretation System That Significantly Predicts HIV-Therapy Response

  • Authors: Camacho R, Clotet B, De Luca A, Geretti AM, Grossman Z, Kaiser R, Prosperi M, Schmit JC, Sönnerborg A, Torti C, Van Wijngaerden E, Vercauteren J, Zazzi M, Beheydt G, Imbrechts S, Libin P, Vandamme AM, Van Laethem K
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061436

Clinically evaluating genotypic interpretation systems is essential to provide optimal guidance in designing potent individualized HIV-regimens. This study aimed at investigating the ability of the latest Rega algorithm to predict virological response on a short and longer period.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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1349-008 Lisboa
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Funding

UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025

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  • Universidade Nova de Lisboa
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    UIDB/04413/2020
    UIDP/04413/2020

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