Enhanced Detection of Tuberculous Mycobacteria in Animal Tissues Using a Semi-Nested Probe-Based Real-Time PCR

Authors: Albuquerque T, Amaro A, Botelho A, Costa P, Couto I, Cunha MV, Ferreira AS, Inácio J, Viveiros M
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081337

Bovine tuberculosis has been tackled for decades by costly eradication programs in most developed countries, involving the laboratory testing of tissue samples from allegedly infected animals for detection of Mycobacterium tuberculosis complex (MTC) members, namely Mycobacterium bovis. Definitive diagnosis is usually achieved by bacteriological culture, which may take up to 6–12 weeks, during which the suspect animal carcass and herd are under sanitary arrest.
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The “far-west” of Anopheles gambiae molecular forms.

Authors: Besansky NJ, Caputo B, Conway DJ, Della Torre A, Jaenson T, Jawara M, Mancini E, Nwakanma DC, Palsson K, Petrarca V, Santolamazza F, Vicente JL, White BJ
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+%E2%80%9Cfar-west%E2%80%9D+of+Anopheles+gambiae+molecular+forms

The main Afrotropical malaria vector, Anopheles gambiae sensu stricto, is undergoing a process of sympatric ecological diversification leading to at least two incipient species (the M and S molecular forms) showing heterogeneous levels of divergence across the genome.
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Therapeutic Potential of Caspofungin Combined with Trimethoprim-Sul- famethoxazole for Pneumocystis Pneumonia: A Pilot Study in Mice

Authors: Antunes F, Cardoso F, Cushion MT, Esteves F, Lobo ML, Matos O
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/23940606

Pneumocystis pneumonia (PcP) is a major cause of mortality and morbidity in immunocompromised patients. There are limited alternative therapeutic choices to trimethoprim-sulfamethoxazole (TMP-SMX) which is the standard first line therapy/prophylaxis for PcP.
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Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe

Authors: Balotta C, Clotet B, Demetriou VL, Grossman Z, Jørgensen LB, Kostrikis LG, Kousiappa I, Lepej SZ, Levy I, Nielsen C, Paraskevis D, Poljak M, Roman F, Ruiz L, Schmidt JC, Van de Vijver DA, Vercauteren J, Vandamme AM, Van Laethem K
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/20544014

BACKGROUND:
HIV-1 genotypic drug resistance is an important threat to the success of antiretroviral therapy and transmitted resistance has reached 9% prevalence in Europe. Studies have demonstrated that HIV-1 DNA load in peripheral blood mononuclear cells (PBMC) have a predictive value for disease progression, independently of CD4 counts and plasma viral load.
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High GUD incidence in the early 20 century created a particularly permissive time window for the origin and initial spread of epidemic HIV strains

Authors: de Sousa JD, Lemey P, Müller V, Vandamme AM
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=High+GUD+Incidence+in+the+Early+20(th)+Century+Created+a+Particularly+Permissive+Time+Window+for+the+Origin+and+Initial+Spread+of+Epidemic+HIV+Strains

The processes that permitted a few SIV strains to emerge epidemically as HIV groups remain elusive. Paradigmatic theories propose factors that may have facilitated adaptation to the human host (e.g., unsafe injections), none of which provide a coherent explanation for the timing, geographical origin, and scarcity of epidemic HIV strains.
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Enhanced Detection of Tuberculous Mycobacteria in Animal Tissues Using a Semi-Nested Probe-Based Real-Time PCR

The “far-west” of Anopheles gambiae molecular forms.

Therapeutic Potential of Caspofungin Combined with Trimethoprim-Sul- famethoxazole for Pneumocystis Pneumonia: A Pilot Study in Mice

Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe

High GUD incidence in the early 20 century created a particularly permissive time window for the origin and initial spread of epidemic HIV strains

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