Comparison of HIV-1 Genotypic Resistance Test Interpretation Systems in Predicting Virological Outcomes Over Time

BACKGROUND: Several decision support systems have been developed to interpret HIV-1 drug resistance genotyping results. This study compares the ability of the most commonly used systems (ANRS, Rega, and Stanford’s HIVdb) to predict virological outcome at 12, 24, and 48 weeks. METHODOLOGY/PRINCIPAL FINDINGS: Included were 3763 treatment-change episodes (TCEs) for which a HIV-1 genotype was […]
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Identification and functional characterization of CRK12:CYC9, a novel cyclin-dependent kinase (CDK)-cyclin complex in Trypanosoma brucei

Authors: Benz C, Burchmore R, Costa CIA, Forkert A, Hamilton A, Hammarton TC, Monnerat S, Mottram JC, Novo C, Tetley L
Publication Year: 2013
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067327

The protozoan parasite, Trypanosoma brucei, is spread by the tsetse fly and causes trypanosomiasis in humans and animals. Both the life cycle and cell cycle of the parasite are complex. Trypanosomes have eleven cdc2-related kinases (CRKs) and ten cyclins, an unusually large number for a single celled organism. To date, relatively little is known about the function of many of the CRKs and cyclins, and only CRK3 has previously been shown to be cyclin-dependent in vivo.
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The origins of African Plasmodium vivax; insights from mitochondrial genome sequencing.

Authors: Andrianaranjaka V, Arez AP, Carter R, Coban C, Cravo P, Culleton R, Farnert A, Kaneko A, Kano S, Randrianarivelojosia M, Sharp PM, Tanabe K, Zeyrek FY
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+origins+of+African+Plasmodium+vivax%3B+insights+from+mitochondrial+genome+sequencing

Plasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human population.
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Urban Planning and Health Inequities: Looking in a Small-Scale in a City of Cape Verde

Authors: Alves D, Amado M, Cabral J, Correia A, Craveiro I, Delgado AP, Gonçalves L, Lapão LV, Santos Z, Simões R
Publication Year: 2015
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142955

The lack of high-quality data to support evidence-based policies continues to be a concern in African cities, which present marked social, economic and cultural disparities that may differently impact the health of the groups living in different urban contexts. This study explores three urban units—formal, transition and informal—of the capital of Cape Verde, in terms of overweight/obesity, cardiometabolic risk, physical activity and other aspects related to the urban environment.
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New Insights into the Population Structure of Anopheles gambiae s.s. in the Gulf of Guinea Islands Revealed by Herves Transposable Elements

Authors: Moreno M, O’Brochta D, Salgueiro P, Simard F, Pinto J
Journal: PLoS One
Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062964

Transposable elements (TEs) are mobile portions of DNA that are able to replicate and spread in the genome of many organisms. TEs can be used as a means to insert transgenes in insects, being stably inherited throughout generations.
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Comparison of HIV-1 Genotypic Resistance Test Interpretation Systems in Predicting Virological Outcomes Over Time

Identification and functional characterization of CRK12:CYC9, a novel cyclin-dependent kinase (CDK)-cyclin complex in Trypanosoma brucei

The origins of African Plasmodium vivax; insights from mitochondrial genome sequencing.

Urban Planning and Health Inequities: Looking in a Small-Scale in a City of Cape Verde

New Insights into the Population Structure of Anopheles gambiae s.s. in the Gulf of Guinea Islands Revealed by Herves Transposable Elements

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