Trypanosoma cruzi IV causing outbreaks of acute Chagas disease and infections by different haplotypes in the Western Brazilian Amazonia

Authors: Barbosa Md, Borges L, de Sá AR, Gomes ML, Guerra JA, Magalhaes LK, Monteiro WM, Pires I, Silveira H, Toledo MJ
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Trypanosoma+cruzi+IV+Causing+Outbreaks+of+Acute+Chagas+Disease+and+Infections+by+Different+Haplotypes+in+the+Western+Brazilian+Amazonia.

Chagas disease is an emergent tropical disease in the Brazilian Amazon Region, with an increasing number of cases in recent decades. In this region, the sylvatic cycle of Trypanosoma cruzi transmission, which constitutes a reservoir of parasites that might be associated with specific molecular, epidemiological and clinical traits, has been little explored.
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Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria

Authors: Amorim A, Arez AP, Cano J, Chibute S, Do Rosário VE, Fernandes N, Gomes C, Langa J, Machado P, Manco L, Mendes C, Miranda J, Pinto J, Ribeiro L, Salomé G, Sitoe L
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Pyruvate+Kinase+Deficiency+in+Sub-Saharan+Africa%3A+Identification+of+a+Highly+Frequent+Missense+Mutation+(G829A%3B+Glu277Lys)+and+Association+with+Malaria

BACKGROUND:
Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries, as well as finding a prevalent PK variant underlying this deficiency.
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Bayesian Latent Class Models in malaria diagnosis

Authors: de Oliveira MR, Do Rosário V, Gonçalves L, Lee PW, Shaio MF, Subtil A
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/22844405

The main focus of this study is to illustrate the importance of the statistical analysis in the evaluation of the accuracy of malaria diagnostic tests, without admitting a reference test, exploring a dataset (n=3317) collected in São Tomé and Príncipe.
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Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

Authors: Afonso C, Almeida AP, Frischknecht F, Gardner R, Gomes-Santos CS, Henriques R, Itoe MA, Moita LF, Mota MM, Raquel H, Sepúlveda N, Simões PD
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Highly+Dynamic+Host+Actin+Reorganization+around+Developing+Plasmodium+Inside+Hepatocytes

Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown.
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KDNA genetic signatures obtained by LSSP-PCR analysis of Leishmania (Leishmania) infantum isolated from the new and the old world.

Authors: Alvarenga JS, Campino L, Cortes S, Gontijo CM, Ligeiro CM, Melo MN, Vago AR
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=KDNA+Genetic+Signatures+Obtained+by+LSSP-PCR+Analysis+of+Leishmania+(Leishmania)+infantum+Isolated+from+the+New+and+the+Old+World

BACKGROUND:
Visceral Leishmaniasis (VL) caused by species from the Leishmania donovani complex is the most severe form of the disease, lethal if untreated. VL caused by Leishmania infantum is a zoonosis with an increasing number of human cases and millions of dogs infected in the Old and the New World. In this study, L. infantum (syn. L.chagasi) strains were isolated from human and canine VL cases.
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Trypanosoma cruzi IV causing outbreaks of acute Chagas disease and infections by different haplotypes in the Western Brazilian Amazonia

Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria

Bayesian Latent Class Models in malaria diagnosis

Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.

KDNA genetic signatures obtained by LSSP-PCR analysis of Leishmania (Leishmania) infantum isolated from the new and the old world.

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