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Home / Archives for Machado P

Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria

  • Autores: Amorim A, Arez AP, Cano J, Chibute S, Do Rosário VE, Fernandes N, Gomes C, Langa J, Machado P, Manco L, Mendes C, Miranda J, Pinto J, Ribeiro L, Salomé G, Sitoe L
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Pyruvate+Kinase+Deficiency+in+Sub-Saharan+Africa%3A+Identification+of+a+Highly+Frequent+Missense+Mutation+(G829A%3B+Glu277Lys)+and+Association+with+Malaria

BACKGROUND:
Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries, as well as finding a prevalent PK variant underlying this deficiency.
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Malaria: looking for selection signatures in the human PKLR gene region

  • Autores: Amorim A, Arez AP, Do Rosário VE, Fernandes N, Gusmão L, Manco L, Miranda J, Pereira R, Rocha AM
  • Journal: British Journal of Haematology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Malaria%3A+looking+for+selection+signatures+in+the+human+PKLR+gene+region

The genetic component of susceptibility to malaria is both complex and multigenic and the better-known protective polymorphisms are those involving erythrocyte-specific structural proteins and enzymes. In vivo and in vitro data have suggested that pyruvate kinase deficiency, which causes a nonspherocytic haemolytic anaemia, could be protective against malaria severity in humans, but this hypothesis remains […]
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Analysis of malaria associated genetic traits in Cabo Verde, a melting pot of European and sub Saharan settlers

  • Autores: Alves J, Amorim A, Arez AP, Faustino P, Gonçalves N, Gusmão L, Manco L, Silva J, Do Rosário VE, Ribeiro L, Machado P
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Analysis+of+malaria+associated+genetic+traits+in+Cabo+Verde%2C+a+melting+pot+of+European+and+sub+Saharan+settlers

Malaria has occurred in the Cabo Verde archipelago with epidemic characteristics since its colonization. Nowadays, it occurs in Santiago Island alone and though prophylaxis is not recommended by the World Health Organization, studies have highlight the prospect of malaria becoming a serious public health problem as a result of the presence of antimalarial drug resistance associated with mutations in the parasite populations and underscore the need for tighter surveillance.
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Triosephosphate isomerase gene promoter variation:-5G/A and-8G/A polymorphisms in clinical malaria groups in two African populations

  • Autores: Arez AP, Fernandes N, Guerra M, Machado P, Manco L, Miranda J
  • Ano de Publicação: 2015
  • Journal: Infection Genetics and Evolution
  • Link: https://www.sciencedirect.com/science/article/pii/S1567134815001057?via%3Dihub

TPI1 promoter polymorphisms occur in high prevalence in individuals from African origin. Malaria-patients from Angola and Mozambique were screened for the TPI1 gene promoter variants rs1800200A>G, (-5G>A), rs1800201G>A, (-8G>A), rs1800202T>G, (-24T>G), and for the intron 5 polymorphism rs2071069G>A, (2262G>A). -5G>A and -8G>A variants occur in 47% and 53% in Angola and Mozambique, respectively while -24T>G […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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