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Home / Archives for Langa J

Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria

  • Authors: Amorim A, Arez AP, Cano J, Chibute S, Do Rosário VE, Fernandes N, Gomes C, Langa J, Machado P, Manco L, Mendes C, Miranda J, Pinto J, Ribeiro L, Salomé G, Sitoe L
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Pyruvate+Kinase+Deficiency+in+Sub-Saharan+Africa%3A+Identification+of+a+Highly+Frequent+Missense+Mutation+(G829A%3B+Glu277Lys)+and+Association+with+Malaria

BACKGROUND:
Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries, as well as finding a prevalent PK variant underlying this deficiency.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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