Highly dynamic host actin reorganization around developing Plasmodium inside hepatocytes.
- Autores: Afonso C, Almeida AP, Frischknecht F, Gardner R, Gomes-Santos CS, Henriques R, Itoe MA, Moita LF, Mota MM, Raquel H, Sepúlveda N, Simões PD
- Journal: PLoS One
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Highly+Dynamic+Host+Actin+Reorganization+around+Developing+Plasmodium+Inside+Hepatocytes
Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside a parasitophorous vacuole. The nature of the Plasmodium-host cell interface, as well as the interactions occurring between these two organisms, remains largely unknown.