Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi.

Authors: Acosta N, Bhattacharyya T, Carrasco HJ, Diosque P, Lewis MD, Llewellyn MS, Mauricio IL, Messenger LA, Miles MA, Yeo M
Journal: Plos Neglected Tropical Diseases
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Multilocus+sequence+typing+(MLST)+for+lineage+assignment+and+high+resolution+diversity+studies+in+Trypanosoma+cruzi

BACKGROUND:
Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable genetic and ecological diversity. A standardised MLST protocol that is suitable for assignment of T. cruzi isolates to genetic lineage and for higher resolution diversity studies has not been developed.
Read More

Visualisation of Leishmania donovani fluorescent hybrids during early stage development in the sand fly vector.

Authors: Lewis MD, Maurício I, Miles MA, Sadlova J, Seblova V, Volf P, Yeo M
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Visualisation+of+Leishmania+donovani+fluorescent+hybrids+during+early+stage+development+in+the+sand+fly+vector

BACKGROUND:
The Leishmania protozoan parasites cause devastating human diseases. Leishmania have been considered to replicate clonally, without genetic exchange. However, an accumulation of evidence indicates that there are inter-specific and intra-specific hybrids among natural populations.
Read More

Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi.

Visualisation of Leishmania donovani fluorescent hybrids during early stage development in the sand fly vector.

About GHTM

Contacts

Map