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Home / Archives for Camacho R

Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe

  • Authors: Asboe D, Bansi L, Camacho R, Codoñer FM, De Luca A, Di Giambenedetto S, Dunn D, Fanti I, Ghisetti V, Kaiser R, Prosperi MCF, Sönnerborg A, Torti C, van de Vijver DC, Van Laethem K, Vandamme AM, Zazzi M
  • Publication Year: 2013
  • Journal: Journal of Infectious Diseases
  • Link: http://jid.oxfordjournals.org/content/early/2013/01/11/infdis.jit017.abstract

HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20,323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering the cumulative genotype) and peaked at 4.5% in 2005, decreasing thereafter. The proportion of cases exhausting available drug options dropped from 32% in 2000 to 1% in 2008. Reduced risk of resistance over calendar years was confirmed by multivariable analysis.
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Study of the regimen-specific HIV-1 genotypic susceptibility score after treatment failure

  • Authors: Camacho R, Carvalho AP, Diogo I, Grossman Z, Ram D, Rudich H, Zazzi M, Beheydt G, Vandamme AM, Van Laethem K
  • Journal: Antiviral Therapy
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=3&SID=Z1yZbyGlNxI3xGo9eDj&page=1&doc=1

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Expected HIV-1 etravirine resistance after treatment failure with efavirenz and/or nevirapine

  • Authors: Camacho R, Carvalho AP, Grossman Z, Levy I, Ram D, Rudich H, Vercauteren J, Beheydt G, Vandamme AM, Van Laethem K
  • Journal: Antiviral Therapy
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=2&SID=Z1yZbyGlNxI3xGo9eDj&page=1&doc=1

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Origin and Epidemiological History of HIV-1 CRF14_BG

  • Authors: Abecasis AB, Barroso H, Bártolo I, Borrego P, Camacho R, Gomes P, McCutchan F, Taveira N
  • Journal: PLoS One
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=26&SID=P2WA5hwy5j35Sqjoq2z&page=1&doc=1

Background: CRF14_BG isolates, originally found in Spain, are characterized by CXCR4 tropism and rapid disease progression. This study aimed to identify the origin of CRF14_BG and reconstruct its epidemiological history based on new isolates from Portugal.
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Clinical Evaluation of Rega 8: An Updated Genotypic Interpretation System That Significantly Predicts HIV-Therapy Response

  • Authors: Camacho R, Clotet B, De Luca A, Geretti AM, Grossman Z, Kaiser R, Prosperi M, Schmit JC, Sönnerborg A, Torti C, Van Wijngaerden E, Vercauteren J, Zazzi M, Beheydt G, Imbrechts S, Libin P, Vandamme AM, Van Laethem K
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061436

Clinically evaluating genotypic interpretation systems is essential to provide optimal guidance in designing potent individualized HIV-regimens. This study aimed at investigating the ability of the latest Rega algorithm to predict virological response on a short and longer period.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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