GHTM

Global Health and Tropical Medicine

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Home / Archives for Narciso J

Decreasing population selection rates of resistance mutation K65R over time in HIV-1 patients receiving com- bination therapy including tenofovir

  • Authors: Abecasis AB, Abreu R, Aguas MJ, Aldir I, Aleixo MJ, Amaro G, Antunes F, Borges F, Botas J, Branco T, Caixas U, Camacho RJ, Diniz A, Doroana M, Duque L, Faria D, Faria N, Faria T, Fonseca P, Germano I, Gomes F, Guerreiro C, Jesus MB, Mansinho K, Mineiro A, Miranda AC, Narciso J, Neves I, Nina J, Pinheiro S, Pinto IV, Proença P, Reis AP, Roxo F, Sá J, Santos C, Snoeck J, Tavares L, Teófilo E, Theys K, Valadas E, Vandamme AM, Ventura F, Vera J, Vercauteren J
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23027713

The use of tenofovir is highly associated with the emergence of mutation K65R, which confers broad resistance to nucleoside/nucleotide analogue reverse transcriptase inhibitors (NRTIs), especially when tenofovir is combined with other NRTIs also selecting for K65R. Although recent HIV-1 treatment guidelines discouraging these combinations resulted in reduced K65R selection with tenofovir, updated information on the impact of currently recommended regimens on the population selection rate of K65R is presently lacking.
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HIV-2 Integrase Polymorphisms and Longitudinal Genotypic Analysis of HIV-2 Infected Patients Failing a Raltegravir-Containing Regimen

  • Authors: Abecasis A, Aguas MJ, Almeida I, Camacho RJ, Cavaco-Silva J, Cunha C, Diniz A, Germano I, Gomes P, Gonçalves Mde F, Maltez F, Miranda AC, Narciso J, Poças J, Portuguese HIV-2 Resistance Study Group
  • Publication Year: 2014
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092747

To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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