Global Health and Tropical Medicine
Title Escape from neutralization is a frequent event in HIV-2 infection and is strongly associated with X4 tropism. Background HIV-2 infection induces the production of a broad neutralizing antibody (NAb) response and this has been linked to a better control of viral replication and disease progression. However, little is known about the neutralizing targets and […]
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BACKGROUND:
The baseline susceptibility of primary HIV-2 to maraviroc (MVC) and other entry inhibitors is currently unknown.
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OBJECTIVES:
To characterize the nature and dynamics of the neutralizing antibody (NAb) response and escape in chronically HIV-2 infected patients.
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The use of tenofovir is highly associated with the emergence of mutation K65R, which confers broad resistance to nucleoside/nucleotide analogue reverse transcriptase inhibitors (NRTIs), especially when tenofovir is combined with other NRTIs also selecting for K65R. Although recent HIV-1 treatment guidelines discouraging these combinations resulted in reduced K65R selection with tenofovir, updated information on the impact of currently recommended regimens on the population selection rate of K65R is presently lacking.
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UID/04413/2025 - DOI: 10.54499/UID/04413/2025
UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025
UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025