Decreasing population selection rates of resistance mutation K65R over time in HIV-1 patients receiving com- bination therapy including tenofovir

Authors: Abecasis AB, Abreu R, Aguas MJ, Aldir I, Aleixo MJ, Amaro G, Antunes F, Borges F, Botas J, Branco T, Caixas U, Camacho RJ, Diniz A, Doroana M, Duque L, Faria D, Faria N, Faria T, Fonseca P, Germano I, Gomes F, Guerreiro C, Jesus MB, Mansinho K, Mineiro A, Miranda AC, Narciso J, Neves I, Nina J, Pinheiro S, Pinto IV, Proença P, Reis AP, Roxo F, Sá J, Santos C, Snoeck J, Tavares L, Teófilo E, Theys K, Valadas E, Vandamme AM, Ventura F, Vera J, Vercauteren J
Journal: Journal of Antimicrobial Chemotherapy
Link: http://www.ncbi.nlm.nih.gov/pubmed/23027713

The use of tenofovir is highly associated with the emergence of mutation K65R, which confers broad resistance to nucleoside/nucleotide analogue reverse transcriptase inhibitors (NRTIs), especially when tenofovir is combined with other NRTIs also selecting for K65R. Although recent HIV-1 treatment guidelines discouraging these combinations resulted in reduced K65R selection with tenofovir, updated information on the impact of currently recommended regimens on the population selection rate of K65R is presently lacking.
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Angola’s 2013 dengue outbreak: clinical, laboratory and molecular analyses of cases from four Portuguese institutions

Authors: Abreu C, Antunes A, Atouguia J, Azevedo T, Centeno-Lima S, Conceição C, Mansinho K, Marques N, Moneti V, Nazareth T, Nina J, Parreira R, Sa L, Saraiva da Cunha J, Sarmento A, Seixas J, Teodósio R
Publication Year: 2014
Journal: The Journal of Infection in Developing Countries
Link: http://www.ncbi.nlm.nih.gov/pubmed/25212088

Dengue virus (DENV) is the arbovirus with the widest impact on human health. In Africa in general, and in Angola in particular, the epidemiology and public health impact of DENV is far from clear. However, rapid population growth, unplanned urbanization, increased international travel, and the presence of virus major vector (Aedes aegypti) in the country suggest that DENV transmission may occur.
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Dengue virus serotype 4 and chikungunya virus coinfection in a traveller returning from Luanda, Angola

Authors: Centeno-Lima S, Constantino A, Lopes A, Nina J, Parreira R, Portugal-Calisto D
Publication Year: 2014
Journal: Eurosurveillance
Link: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20730

concurrent dengue virus serotype 4 and chikungunya virus infection was detected in a woman in her early 50s returning to Portugal from Luanda, Angola, in January 2014. The clinical, laboratory and molecular findings, involving phylogenetic analyses of partial viral genomic sequences amplified by RT-PCR, are described.
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Ebolavirosis: a 2014 Review for Clinicians

Authors: Nina J
Publication Year: 2014
Journal: Acta Médica Portuguesa
Link: http://www.ncbi.nlm.nih.gov/pubmed/25409219

Ebolavirosis, like Marburgvirosis, are African zoonosis, and for both the primary animal reservoir are bats. It is a typical acute haemorrhagic fever, characterized by a high lethality rate. In an outbreak, the human index case became infected after contact with an infected animal or its blood, in most cases during hunting.
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Decreasing population selection rates of resistance mutation K65R over time in HIV-1 patients receiving com- bination therapy including tenofovir

Angola’s 2013 dengue outbreak: clinical, laboratory and molecular analyses of cases from four Portuguese institutions

Dengue virus serotype 4 and chikungunya virus coinfection in a traveller returning from Luanda, Angola

Ebolavirosis: a 2014 Review for Clinicians

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