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Home / Archives for Journal of Antimicrobial Chemotherapy

Effectiveness of integrase strand transfer inhibitor-based regimens in HIV-infected treatment-naive individuals: results from a European multi-cohort study

  • Autores: Barbara Rossetti, Massimiliano Fabbiani, Domenico Di Carlo, Francesca Incardona, Ana Abecasis, Perpetua Gomes, Anna Maria Geretti, Carole Seguin-Devaux, Federico Garcia, Rolf Kaiser, Sara Modica, Adrian Shallvari, Anders Sönnerborg, Maurizio Zazzi, EuResist Network, INTEGRATE study group
  • Ano de Publicação: 2021
  • Journal: Journal of Antimicrobial Chemotherapy, 76(9), pp 2394–2399
  • Link: https://doi.org/10.1093/jac/dkab200

ABSTRACT ‘Background:’ INSTIs have become a pillar of first-line ART. Real-world data are needed to assess their effectiveness in routine care. ‘Objectives:’ We analysed ART-naive patients who started INSTI-based regimens in 2012–19 whose data were collected by INTEGRATE, a European collaborative study including seven national cohorts. ‘Methods:’ Kaplan–Meier analyses assessed time to virological failure (VF), […]
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Pneumocystis jirovecii pneumonia: Still a concern in patients with haematological malignancies and stem cell transplant recipients-authors’ response

  • Autores: a joint venture of The European Group for Blood and Marrow Transplantation (EBMT), Alanio A, Bretagne S, Cesaro S, Cordonnier C, Donnelly JP, Einsele H, Fifth European Conference on Infections in Leukemia (ECIL-5), Hauser PM, Helweg-Larsen J, Lagrou K, Maertens J, Maschmeyer G, Matos O, Melchers WJ, the European LeukemiaNet (ELN), The European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS)
  • Ano de Publicação: 2017
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: https://academic.oup.com/jac/article/72/4/1266/2957000%20

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Active antimicrobial efflux in Staphylococcus epidermidis: building up of resistance to fluoroquinolones and biocides in a major opportunistic pathogen

  • Autores: Costa SS, Couto I, Pomba C, Viveiros M
  • Ano de Publicação: 2017
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: https://academic.oup.com/jac/article/73/2/320/4604698

To analyse the efflux-mediated response of Staphylococcus epidermidis to ethidium bromide (EtBr), a substrate of multidrug efflux pumps (EPs). The susceptible reference strain S. epidermidis ATCC 12228 was exposed to a step-wise adaptation to EtBr. The resulting EtBr-adapted strains were characterized regarding their antibiotic and biocide susceptibility by MIC determination and evaluation of efflux activity […]
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ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients

  • Autores: 5th European Conference on Infections in Leukaemia (ECIL-5), a joint venture of The European Group for Blood and Marrow Transplantation (EBMT), Alanio A, Bretagne S, Cesaro S, Cordonnier C, Donnelly JP, Einsele H, Hauser PM, Helweg-Larsen J, Lagrou K, Maertens J, Maschmeyer G, Matos O, Melchers WJ, The European Organization for Research and Treatment of Cancer (EORTC), the European LeukemiaNet (ELN), the Immunocompromised Host Society (ICHS)
  • Ano de Publicação: 2016
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkw156

The Fifth European Conference on Infections in Leukaemia (ECIL-5) convened a meeting to establish evidence-based recommendations for using tests to diagnose Pneumocystis jirovecii pneumonia (PCP) in adult patients with haematological malignancies. Immunofluorescence assays are recommended as the most sensitive microscopic method (recommendation A-II: ). Real-time PCR is recommended for the routine diagnosis of PCP ( […]
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ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients

  • Autores: 5th European Conference on Infections in Leukaemia (ECIL-5), a joint venture of The European Group for Blood and Marrow Transplantation (EBMT), Alanio A, Bretagne S, Cesaro S, Cordonnier C, Donnelly JP, Einsele H, Hauser PM, Helweg-Larsen J, Lagrou K, Maertens J, Maschmeyer G, Matos O, Melchers WJ, the European LeukemiaNet (ELN), The European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS)
  • Ano de Publicação: 2016
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: https://academic.oup.com/jac/article/71/9/2397/2237828

The 5th European Conference on Infections in Leukaemia (ECIL-5) meeting aimed to establish evidence-based recommendations for the prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in non-HIV-infected patients with an underlying haematological condition, including allogeneic HSCT recipients. Recommendations were based on the grading system of the IDSA. Trimethoprim/sulfamethoxazole given 2-3 times weekly is the drug of choice […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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